Table 1.

Induced hematopoietic lineage switches

Cell type of originResulting cell typeType of manipulationReference
Pre–B lymphoma cell line Macrophages 5-azacytidine treatment 6  
Eu-Myc B lymphoma lines Macrophages v-raf expr 7  
Pre–B cell lines Macrophages v-fms, CSF1-R plus CSF1 8  
Pre–B lymphoma Neutrophil granulocytes Transplantation 9  
Pax-5−/− pre–B cells Mac/Gr, dendrites, NK cells Different cytokines 11  
Pax-5−/− pre–B cells As above, plus T cells Transplanted into Rag2−/− 10  
Lymphoid prog. (CLPs) GM-CSF IL-2 Rα expr, IL-2 13  
CD19+ B220cells Macrophages Myeloid culture conditions 14  
Pro–T cells Macrophages Conditioned medium 22  
Macrophage cell line (70Z/3) B-lineage cells E2A, EBF expr 15  
MEP cells Myeloid cells Inducible PU.1 expr 30  
MEP cells Eosinophils Inducible C/EBP expr 31,41  
Myeloid cell line (HD50M) Eosinophils Inducible GATA-1 expr 32  
Myeloid cell line (HD50M) MEPs; erythrocytes High GATA-1 expr; ts Ets 32  
Eosinophil cell line (1A1) MEP cells FOG-1 expr 33  
Erythroid cell line (MEL) Macrophagelike cells Inducible PU.1 expr 34  
Myeloid cell line (416B) Megakaryocytic cells GATA-1, GATA-2 expr 35  
Myeloid cell line (FDCW2) Erythroid cells GATA-1 expr 36  
Myeloid cell line (M1) Megakar, erythroid cells GATA-1 expr 37  
GM precursors Ery, eosin, basoph cells Inducible GATA-1 T. Enver pers comm., September 2001 
Cell type of originResulting cell typeType of manipulationReference
Pre–B lymphoma cell line Macrophages 5-azacytidine treatment 6  
Eu-Myc B lymphoma lines Macrophages v-raf expr 7  
Pre–B cell lines Macrophages v-fms, CSF1-R plus CSF1 8  
Pre–B lymphoma Neutrophil granulocytes Transplantation 9  
Pax-5−/− pre–B cells Mac/Gr, dendrites, NK cells Different cytokines 11  
Pax-5−/− pre–B cells As above, plus T cells Transplanted into Rag2−/− 10  
Lymphoid prog. (CLPs) GM-CSF IL-2 Rα expr, IL-2 13  
CD19+ B220cells Macrophages Myeloid culture conditions 14  
Pro–T cells Macrophages Conditioned medium 22  
Macrophage cell line (70Z/3) B-lineage cells E2A, EBF expr 15  
MEP cells Myeloid cells Inducible PU.1 expr 30  
MEP cells Eosinophils Inducible C/EBP expr 31,41  
Myeloid cell line (HD50M) Eosinophils Inducible GATA-1 expr 32  
Myeloid cell line (HD50M) MEPs; erythrocytes High GATA-1 expr; ts Ets 32  
Eosinophil cell line (1A1) MEP cells FOG-1 expr 33  
Erythroid cell line (MEL) Macrophagelike cells Inducible PU.1 expr 34  
Myeloid cell line (416B) Megakaryocytic cells GATA-1, GATA-2 expr 35  
Myeloid cell line (FDCW2) Erythroid cells GATA-1 expr 36  
Myeloid cell line (M1) Megakar, erythroid cells GATA-1 expr 37  
GM precursors Ery, eosin, basoph cells Inducible GATA-1 T. Enver pers comm., September 2001 

Prog indicates, progenitor; expr, expression; megakary, megakaryocyte; ery, erythrocyte; eosin, eosinophil; basoph, basophil; and pers comm, personal communication.

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