Cox models for PFS and OS
| Variable4-150 . | Variable estimate . | P2 . | Relative risk (95% CI) . |
|---|---|---|---|
| PFS: all patients (n = 50) | |||
| No. of extranodal sites (2-5 vs 0-1) | 0.88 | .08 | 2.42 (0.90-6.50) |
| PFS: patients with marker data (n = 29) | |||
| Bcl-2 positive vs bcl-2 negative | 1.35 | .05 | 3.86 (0.99-14.96) |
| PFS: Bcl-2 status adjusted for IPI score (n = 29) | |||
| Bcl-2 positive vs bcl-2 negative | 1.49 | .04 | 4.42 (1.10-17.69) |
| Modified IPI score (3-5 vs 0-2) | 0.64 | .33 | 1.90 (0.52-6.89) |
| OS: all patients (n = 50) | |||
| Modified IPI score (3-5 vs 0-2) | 1.60 | .015 | 4.96 (1.36-18.06) |
| OS: patients with marker data (n = 33) | |||
| Modified IPI score (3-5 vs 0-2) | 1.62 | .04 | 5.07 (1.04-24.62) |
| P53 positive vs p53 negative | 1.27 | .06 | 3.54 (0.92-13.54) |
| Variable4-150 . | Variable estimate . | P2 . | Relative risk (95% CI) . |
|---|---|---|---|
| PFS: all patients (n = 50) | |||
| No. of extranodal sites (2-5 vs 0-1) | 0.88 | .08 | 2.42 (0.90-6.50) |
| PFS: patients with marker data (n = 29) | |||
| Bcl-2 positive vs bcl-2 negative | 1.35 | .05 | 3.86 (0.99-14.96) |
| PFS: Bcl-2 status adjusted for IPI score (n = 29) | |||
| Bcl-2 positive vs bcl-2 negative | 1.49 | .04 | 4.42 (1.10-17.69) |
| Modified IPI score (3-5 vs 0-2) | 0.64 | .33 | 1.90 (0.52-6.89) |
| OS: all patients (n = 50) | |||
| Modified IPI score (3-5 vs 0-2) | 1.60 | .015 | 4.96 (1.36-18.06) |
| OS: patients with marker data (n = 33) | |||
| Modified IPI score (3-5 vs 0-2) | 1.62 | .04 | 5.07 (1.04-24.62) |
| P53 positive vs p53 negative | 1.27 | .06 | 3.54 (0.92-13.54) |
CI indicates confidence interval; and IPI, International Prognostic Index.
Variables with greatest significance in Cox proportional hazards model analysis. The Cox model included all individual IPI prognostic factors, combined high IPI risk categories (3-5) versus low modified IPI risk categories (0-2), and marker data where available.