Table 5.

Cox models for PFS and OS

Variable4-150Variable
estimate
P2Relative risk
(95% CI)
PFS: all patients (n = 50)    
 No. of extranodal sites
(2-5 vs 0-1) 
0.88 .08 2.42  (0.90-6.50)  
PFS: patients with marker data
(n = 29) 
   
 Bcl-2 positive vs bcl-2 negative 1.35 .05 3.86  (0.99-14.96)  
PFS: Bcl-2 status adjusted for IPI score (n = 29)    
 Bcl-2 positive vs bcl-2 negative 1.49 .04 4.42  (1.10-17.69)  
 Modified IPI score (3-5 vs 0-2) 0.64 .33 1.90  (0.52-6.89)  
OS: all patients (n = 50)    
 Modified IPI score (3-5 vs 0-2) 1.60 .015 4.96  (1.36-18.06)  
OS: patients with marker data
(n = 33) 
   
 Modified IPI score (3-5 vs 0-2) 1.62 .04 5.07  (1.04-24.62)  
 P53 positive vs p53 negative 1.27 .06 3.54  (0.92-13.54) 
Variable4-150Variable
estimate
P2Relative risk
(95% CI)
PFS: all patients (n = 50)    
 No. of extranodal sites
(2-5 vs 0-1) 
0.88 .08 2.42  (0.90-6.50)  
PFS: patients with marker data
(n = 29) 
   
 Bcl-2 positive vs bcl-2 negative 1.35 .05 3.86  (0.99-14.96)  
PFS: Bcl-2 status adjusted for IPI score (n = 29)    
 Bcl-2 positive vs bcl-2 negative 1.49 .04 4.42  (1.10-17.69)  
 Modified IPI score (3-5 vs 0-2) 0.64 .33 1.90  (0.52-6.89)  
OS: all patients (n = 50)    
 Modified IPI score (3-5 vs 0-2) 1.60 .015 4.96  (1.36-18.06)  
OS: patients with marker data
(n = 33) 
   
 Modified IPI score (3-5 vs 0-2) 1.62 .04 5.07  (1.04-24.62)  
 P53 positive vs p53 negative 1.27 .06 3.54  (0.92-13.54) 

CI indicates confidence interval; and IPI, International Prognostic Index.

F4-150

Variables with greatest significance in Cox proportional hazards model analysis. The Cox model included all individual IPI prognostic factors, combined high IPI risk categories (3-5) versus low modified IPI risk categories (0-2), and marker data where available.

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