Clinical characteristics of patients
| . | Initial diagnosis . | Sex . | Age . | Counts at presentation . | Treatments before cytogenetic conversion . | Response to IST . | |||
|---|---|---|---|---|---|---|---|---|---|
| ANC × 103/μL . | Hemoglobin g/dL . | Reticulocytes × 103/μL . | Platelets × 103/μL . | ||||||
| 1 | sAA | M | 54 | 544 | 6.4 | 28 | 19 | ATG/CsA, androgens | NR |
| 2 | sAA | F | 77 | 48 | 10 | 3.8 | 11 | ATG/CsA, GM-CSF | R |
| 3 | sAA | M | 30 | 660 | 9 | 28 | 9 | ATG/CsA, GM-CSF | R |
| 4 | sAA | M | 51 | 350 | 2 | 9.4 | 21 | ATG/CsA, G-CSF | NR |
| 5 | sAA | F | 42 | 288 | 7.6 | 12 | 7 | ATG/CsA, G-CSF | NR |
| 6 | sAA | M | 8 | 470 | 4 | 5 | 14 | ATG/CsA, GM-CSF, G-CSF, SCF | NR |
| 7 | sAA | M | 63 | 115 | 7 | 7.2 | 6 | ATG/CsA, SCF/G-CSF | NR |
| 8 | sAA | M | 73 | 870 | 9.6 | 28 | 13 | ATG/CsA | NR |
| 9 | sAA | F | 55 | 600 | 9.8 | 30 | 20 | ATG/CsA, androgens | R |
| 10 | sAA | M | 11 | 450 | 10 | 65 | 9 | ATG/CsA | NR |
| 11 | sAA | F | 34 | 660 | 5 | 3 | 8 | ATG/CsA | R |
| 12 | sAA | M | 20 | 230 | 7 | 6 | 3 | ATG/CsA, SCF/G-CSF | NR |
| 13 | sAA | M | 48 | 330 | 9 | 6.8 | 39 | ATG/CsA | R |
| 14 | sAA | F | 45 | 1400 | 10 | 10 | 5 | ATG/CsA | R |
| 15 | sAA | F | 49 | 666 | 9.8 | 47 | 2 | ATG/CsA | R |
| 16 | sAA | M | 66 | 1000 | 5.4 | 32 | 7 | ATG/CsA | NR |
| 17 | sAA | F | 23 | 870 | 5.1 | 29 | 30 | G-CSF/EPO | NT |
| 18 | sAA | M | 67 | 1000 | 3 | 25 | 9 | ATG/CsA | R |
| 19 | sAA | M | 43 | 360 | 9.5 | 7 | 23 | ATG/CsA | R |
| 20 | mAA | F | 54 | 1080 | 6.9 | 40 | 14 | ATG/CsA | R |
| 21 | sAA | M | 61 | 360 | 9.1 | 41 | 20 | ATG/CsA | R |
| 22 | sAA | F | 61 | 120 | 3.5 | 14 | 15 | ATG/CsA, SCF/G-CSF, EPO | NR |
| 23 | sAA | F | 54 | 1068 | 8.2 | 24 | 5 | ATG/CsA, SCF/G-CSF, androgens | NR |
| 24 | sAA | M | 10 | 230 | 9 | 10 | 22 | ATG/CsA, SCF/G-CSF, androgens | NR |
| 25 | sAA | F | 16 | 774 | 6 | 19 | 18 | ATG/CsA | R |
| 26 | sAA | F | 8 | 885 | 9.5 | 50 | 9 | ATG/CsA | R |
| 27 | sAA | M | 48 | 820 | 8 | 21 | 18 | CTX/CsA | R |
| 28 | sAA | M | 27 | 580 | 7.5 | 14 | 10 | ATG/CsA | R |
| 29 | mAA | F | 53 | 1290 | 9 | 53 | 17 | ATG/CsA | R |
| 30 | sAA | M | 34 | 494 | 7.5 | 32 | 16 | ATG/CsA/MMF, ATG/CsA | NR |
| . | Initial diagnosis . | Sex . | Age . | Counts at presentation . | Treatments before cytogenetic conversion . | Response to IST . | |||
|---|---|---|---|---|---|---|---|---|---|
| ANC × 103/μL . | Hemoglobin g/dL . | Reticulocytes × 103/μL . | Platelets × 103/μL . | ||||||
| 1 | sAA | M | 54 | 544 | 6.4 | 28 | 19 | ATG/CsA, androgens | NR |
| 2 | sAA | F | 77 | 48 | 10 | 3.8 | 11 | ATG/CsA, GM-CSF | R |
| 3 | sAA | M | 30 | 660 | 9 | 28 | 9 | ATG/CsA, GM-CSF | R |
| 4 | sAA | M | 51 | 350 | 2 | 9.4 | 21 | ATG/CsA, G-CSF | NR |
| 5 | sAA | F | 42 | 288 | 7.6 | 12 | 7 | ATG/CsA, G-CSF | NR |
| 6 | sAA | M | 8 | 470 | 4 | 5 | 14 | ATG/CsA, GM-CSF, G-CSF, SCF | NR |
| 7 | sAA | M | 63 | 115 | 7 | 7.2 | 6 | ATG/CsA, SCF/G-CSF | NR |
| 8 | sAA | M | 73 | 870 | 9.6 | 28 | 13 | ATG/CsA | NR |
| 9 | sAA | F | 55 | 600 | 9.8 | 30 | 20 | ATG/CsA, androgens | R |
| 10 | sAA | M | 11 | 450 | 10 | 65 | 9 | ATG/CsA | NR |
| 11 | sAA | F | 34 | 660 | 5 | 3 | 8 | ATG/CsA | R |
| 12 | sAA | M | 20 | 230 | 7 | 6 | 3 | ATG/CsA, SCF/G-CSF | NR |
| 13 | sAA | M | 48 | 330 | 9 | 6.8 | 39 | ATG/CsA | R |
| 14 | sAA | F | 45 | 1400 | 10 | 10 | 5 | ATG/CsA | R |
| 15 | sAA | F | 49 | 666 | 9.8 | 47 | 2 | ATG/CsA | R |
| 16 | sAA | M | 66 | 1000 | 5.4 | 32 | 7 | ATG/CsA | NR |
| 17 | sAA | F | 23 | 870 | 5.1 | 29 | 30 | G-CSF/EPO | NT |
| 18 | sAA | M | 67 | 1000 | 3 | 25 | 9 | ATG/CsA | R |
| 19 | sAA | M | 43 | 360 | 9.5 | 7 | 23 | ATG/CsA | R |
| 20 | mAA | F | 54 | 1080 | 6.9 | 40 | 14 | ATG/CsA | R |
| 21 | sAA | M | 61 | 360 | 9.1 | 41 | 20 | ATG/CsA | R |
| 22 | sAA | F | 61 | 120 | 3.5 | 14 | 15 | ATG/CsA, SCF/G-CSF, EPO | NR |
| 23 | sAA | F | 54 | 1068 | 8.2 | 24 | 5 | ATG/CsA, SCF/G-CSF, androgens | NR |
| 24 | sAA | M | 10 | 230 | 9 | 10 | 22 | ATG/CsA, SCF/G-CSF, androgens | NR |
| 25 | sAA | F | 16 | 774 | 6 | 19 | 18 | ATG/CsA | R |
| 26 | sAA | F | 8 | 885 | 9.5 | 50 | 9 | ATG/CsA | R |
| 27 | sAA | M | 48 | 820 | 8 | 21 | 18 | CTX/CsA | R |
| 28 | sAA | M | 27 | 580 | 7.5 | 14 | 10 | ATG/CsA | R |
| 29 | mAA | F | 53 | 1290 | 9 | 53 | 17 | ATG/CsA | R |
| 30 | sAA | M | 34 | 494 | 7.5 | 32 | 16 | ATG/CsA/MMF, ATG/CsA | NR |
NR indicates nonresponsive; R, responsive; MMF, mycophenolate mofetil.