Rescue of CD4+CD8+ thymocytes by radiation in SCID and Eμ-A1 SCID mice
| Group . | Genotype . | Double positive, % . |
|---|---|---|
| Experiment 1 (100 cGy, 16 d) | SCID | 80 |
| SCID | 0.67 | |
| SCID | 0.78 | |
| Eμ-A1 SCID | 1.7 | |
| Eμ-A1 SCID | 9.6 | |
| Eμ-A1 SCID | 2.1 | |
| Experiment 2 (150 cGy, 12 d) | SCID | 1.3 |
| SCID | 19 | |
| SCID | 70 | |
| SCID | 91 | |
| Eμ-A1 SCID | 66 | |
| Experiment 3 (150 cGy, 22 d) | SCID | 84 |
| SCID | 54 | |
| Eμ-A1 SCID | 89 | |
| Eμ-A1 SCID | 12 | |
| Control | SCID | 0.77 ± 0.43 |
| Eμ-A1 SCID | 0.89 ± 0.51 |
| Group . | Genotype . | Double positive, % . |
|---|---|---|
| Experiment 1 (100 cGy, 16 d) | SCID | 80 |
| SCID | 0.67 | |
| SCID | 0.78 | |
| Eμ-A1 SCID | 1.7 | |
| Eμ-A1 SCID | 9.6 | |
| Eμ-A1 SCID | 2.1 | |
| Experiment 2 (150 cGy, 12 d) | SCID | 1.3 |
| SCID | 19 | |
| SCID | 70 | |
| SCID | 91 | |
| Eμ-A1 SCID | 66 | |
| Experiment 3 (150 cGy, 22 d) | SCID | 84 |
| SCID | 54 | |
| Eμ-A1 SCID | 89 | |
| Eμ-A1 SCID | 12 | |
| Control | SCID | 0.77 ± 0.43 |
| Eμ-A1 SCID | 0.89 ± 0.51 |
Offspring of Eμ-A1 SCID × SCID crosses were irradiated at birth with 100 or 150 cGy. At the indicated interval, thymus and bone marrow were analyzed for lymphoid development. Rescue of double-positive thymocytes was calculated as the percentage of cells in lymphoid scatter gates expressing CD4 and CD8 and is given for individual animals. As controls, 5 mice aged 3 to 5 weeks were used, and values reflect the mean ± SD for these groups.