Peripheral lymphoid subsets in Eμ-A1 line 8 mice compared with wild-type littermates
| . | B220+IgM+ . | CD4+ . | CD8+ . | |||
|---|---|---|---|---|---|---|
| % . | Cells (× 10−6) . | % . | Cells (× 10−6) . | % . | Cells (× 10−6) . | |
| Wild-type spleen | 56.0 ± 6.9 | 23.0 ± 9.4 | 24.0 ± 7.2 | 9.0 ± 5.6 | 15.0 ± 5.3 | 5.4 ± 2.9 |
| Eμ-A1 spleen | 49.0 ± 7.4* | 15.0 ± 5.1* | 23.0 ± 14 | 6.3 ± 4.3 | 17.0 ± 7.5 | 4.9 ± 3.2 |
| Wild-type lymph node | 25.0 ± 5.0 | 2.2 ± 1.1 | 36.0 ± 13 | 3.0 ± 1.5 | 28.0 ± 8.9 | 2.3 ± 1.2 |
| Eμ-A1 lymph node | 18.0 ± 5.5 | 1.6 ± 0.71 | 38.0 ± 11 | 3.2 ± 1.7 | 33.0 ± 7.1 | 2.6 ± 1.2 |
| . | B220+IgM+ . | CD4+ . | CD8+ . | |||
|---|---|---|---|---|---|---|
| % . | Cells (× 10−6) . | % . | Cells (× 10−6) . | % . | Cells (× 10−6) . | |
| Wild-type spleen | 56.0 ± 6.9 | 23.0 ± 9.4 | 24.0 ± 7.2 | 9.0 ± 5.6 | 15.0 ± 5.3 | 5.4 ± 2.9 |
| Eμ-A1 spleen | 49.0 ± 7.4* | 15.0 ± 5.1* | 23.0 ± 14 | 6.3 ± 4.3 | 17.0 ± 7.5 | 4.9 ± 3.2 |
| Wild-type lymph node | 25.0 ± 5.0 | 2.2 ± 1.1 | 36.0 ± 13 | 3.0 ± 1.5 | 28.0 ± 8.9 | 2.3 ± 1.2 |
| Eμ-A1 lymph node | 18.0 ± 5.5 | 1.6 ± 0.71 | 38.0 ± 11 | 3.2 ± 1.7 | 33.0 ± 7.1 | 2.6 ± 1.2 |
Lymph node and spleen cells from 4- to 8-week-old mice were counted and analyzed for the indicated subsets using flow cytometry. Values indicate the average percentage or absolute numbers of cells for the indicated subset (± SD) for 6 mice analyzed in each group. For splenic B-cell numbers, the difference is statistically significant.
P < .02, compared to wild-type.