Table 1. Infection status and... | American Society of Hematology

Table 1.

Infection status and clinicopathological findings in rhesus macaques

Animal	Infection duration (wk)^†	Infection stage	Plasma viral copies/mL^‡	SIV ISH^*			IFN-γ ISH^*		Clinicopathological findings
Animal	Infection duration (wk)^†	Infection stage	Plasma viral copies/mL^‡	Spl	AxLN	IngLN	Spl	AxLN	Clinicopathological findings
M5299	2	Acute	10 000 000	45.8	50.0	61.0	9.9	24.8	Mild hypercellularity in LN, gastritis
M5499	2	Acute	6 500 000^1-153	65.9	65.4	44.0	6.9	23.4	Reduced % CD4⁺ T lymphocytes
M5599	2	Acute	54 000	1.5	2.3	1.1	2.9	7.7	None
M5699	2	Acute	63 000 000	28.1	55.2	59.7	25.9	81.8	None
M0999	2	Acute	29 000 000	17.5	8.0	7.3	9.1	2.9	None
M5899	2	Acute	14 000 000^1-153	29.6	5.8	6.2	12.8	5.5	Reduced % CD4⁺ T lymphocytes, mild LH, gastritis
M5999	2	Acute	7 000 000	24.1	32.1	44.0	7.7	49.7	Reduced % CD4⁺ T lymphocytes
M6299	2	Acute	34 000 000	22.6	53.3	77.2	17.2	34.0	Reduced % CD4⁺ T lymphocytes
M1799	21	AIDS	780 000	13.3	7.3	14.6	11.0	9.9	Weight loss, CD4⁺ T-lymphocyte loss, Pc, LH
M5199	24	AIDS	540 000	13.3	28.1	38.4	4.0	16.1	Weight loss, CD4⁺ T-lymphocyte loss, Pc, LH
M6199	32	AIDS	940 000	6.9	15.3	12.8	17.2	8.0	Weight loss, CD4⁺ T-lymphocyte loss, mild encephalitis, LH
M5799	55	AIDS	28 000 000	10.2	13.2	26.3	6.6	5.5	Weight loss, CD4⁺ T-lymphocyte loss, B-lymphocytic lymphoma, LH
M9597^1-154	384	Chronic/LTNP	< 50	0	0	0	23.4	2.2	Mild LH
M5600	NA	Uninfected	ND	0	0	0	1.5	0.7	None
M6600	NA	Uninfected	ND	0	0	0	1.8	0.4	None

Animal	Infection duration (wk)^†	Infection stage	Plasma viral copies/mL^‡	SIV ISH^*			IFN-γ ISH^*		Clinicopathological findings
Animal	Infection duration (wk)^†	Infection stage	Plasma viral copies/mL^‡	Spl	AxLN	IngLN	Spl	AxLN	Clinicopathological findings
M5299	2	Acute	10 000 000	45.8	50.0	61.0	9.9	24.8	Mild hypercellularity in LN, gastritis
M5499	2	Acute	6 500 000^1-153	65.9	65.4	44.0	6.9	23.4	Reduced % CD4⁺ T lymphocytes
M5599	2	Acute	54 000	1.5	2.3	1.1	2.9	7.7	None
M5699	2	Acute	63 000 000	28.1	55.2	59.7	25.9	81.8	None
M0999	2	Acute	29 000 000	17.5	8.0	7.3	9.1	2.9	None
M5899	2	Acute	14 000 000^1-153	29.6	5.8	6.2	12.8	5.5	Reduced % CD4⁺ T lymphocytes, mild LH, gastritis
M5999	2	Acute	7 000 000	24.1	32.1	44.0	7.7	49.7	Reduced % CD4⁺ T lymphocytes
M6299	2	Acute	34 000 000	22.6	53.3	77.2	17.2	34.0	Reduced % CD4⁺ T lymphocytes
M1799	21	AIDS	780 000	13.3	7.3	14.6	11.0	9.9	Weight loss, CD4⁺ T-lymphocyte loss, Pc, LH
M5199	24	AIDS	540 000	13.3	28.1	38.4	4.0	16.1	Weight loss, CD4⁺ T-lymphocyte loss, Pc, LH
M6199	32	AIDS	940 000	6.9	15.3	12.8	17.2	8.0	Weight loss, CD4⁺ T-lymphocyte loss, mild encephalitis, LH
M5799	55	AIDS	28 000 000	10.2	13.2	26.3	6.6	5.5	Weight loss, CD4⁺ T-lymphocyte loss, B-lymphocytic lymphoma, LH
M9597^1-154	384	Chronic/LTNP	< 50	0	0	0	23.4	2.2	Mild LH
M5600	NA	Uninfected	ND	0	0	0	1.5	0.7	None
M6600	NA	Uninfected	ND	0	0	0	1.8	0.4	None

SIV indicates simian immunodeficiency virus; ISH, in situ hybridization; IFN-γ, interferon γ; Spl, spleen; AxLN, axillary lymph nodes; IngLN, inguinal lymph nodes; LN, lymph nodes; LH, lymphoid hyperplasia; AIDS, acquired immunodeficiency syndrome; Pc,Pneumocystis carinii infection; LTNP, long-term nonprogressor; NA, not applicable; and ND, not done.

Numbers of RNA-positive cells/mm² determined by ISH.

†

All macaques were inoculated intravenously with a characterized stock of the pathogenic isolate SIV/ΔB670.6

‡

Real-time reverse transcriptase–polymerase chain reaction was used to determine plasma viral loads.

F1-153

Values for samples obtained 2 weeks after infection were not available; values are for the week 1 time point.

F1-154

This animal was an LTNP that was described previously.7

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