Table 1. V gene profiles and incidence... | American Society of Hematology

Table 1.

V gene profiles and incidence of novel N-glycosylation sites resulting from somatic mutation in patients with FL

V_H					V_L				Total
Patient	Germline donor	Homology (%)	J_H	No. sites	Germline donor	Homology (%)	J_L	No. sites	Total
F1	V3-48	89	JH3a	1	VκIII/A27	95	Jκ1	0	1
F2	V3-48	92	JH3b	1	VκIV/B3	96	Jκ4	1	2
F7	V3-48	93	JH4a	2	VκI/012	86	Jκ3	1	3
F8	V3-48	80	JH4	2	VκIII/L2	96	Jκ4	1	3
F10	V3-48	89	JH4b	1	VκI/02	92	Jκ2	0	1
F11	V3-48	91	JH6b	2	VκI/A30	97	Jκ1	0	2
F15	V3-48	96	JH5a	1	VκIII/L6	97	Jκ4	1	2
F12	V3-48	89	JH6b	1	VκII/A17	99	Jκ3	1	2
F4^*	V3-11	91	JH6c	2	VκIII/L6	96	Jκ4	1	3
F72	V3-15	92	JH4b	1	VκI/A30	95	Jκ2	0	1
F17	V3-21	91	JH4	1	Vλ1c	94	Jλ2	0	1
F6	V3-30	87	JH4b	0	VκI/012	97	Jκ2	1	1
F3	V3-49	87	JH6b	2	VκI/012	88	Jκ1	1	3
F14	P1^†	87	JH4b	1	VκIV/B3	94	Jκ1	0	1
F5^*	V4-34	83	JH2	1	VκIII/A27	89	Jκ2	1	2
F9	V4-39	86	JH5b	1	VκIV/A26	98	Jκ2	0	1
F16^*	V4-59	86	JH4b	1	Vλ1	96	Jλ2	1	2

V_H					V_L				Total
Patient	Germline donor	Homology (%)	J_H	No. sites	Germline donor	Homology (%)	J_L	No. sites	Total
F1	V3-48	89	JH3a	1	VκIII/A27	95	Jκ1	0	1
F2	V3-48	92	JH3b	1	VκIV/B3	96	Jκ4	1	2
F7	V3-48	93	JH4a	2	VκI/012	86	Jκ3	1	3
F8	V3-48	80	JH4	2	VκIII/L2	96	Jκ4	1	3
F10	V3-48	89	JH4b	1	VκI/02	92	Jκ2	0	1
F11	V3-48	91	JH6b	2	VκI/A30	97	Jκ1	0	2
F15	V3-48	96	JH5a	1	VκIII/L6	97	Jκ4	1	2
F12	V3-48	89	JH6b	1	VκII/A17	99	Jκ3	1	2
F4^*	V3-11	91	JH6c	2	VκIII/L6	96	Jκ4	1	3
F72	V3-15	92	JH4b	1	VκI/A30	95	Jκ2	0	1
F17	V3-21	91	JH4	1	Vλ1c	94	Jλ2	0	1
F6	V3-30	87	JH4b	0	VκI/012	97	Jκ2	1	1
F3	V3-49	87	JH6b	2	VκI/012	88	Jκ1	1	3
F14	P1^†	87	JH4b	1	VκIV/B3	94	Jκ1	0	1
F5^*	V4-34	83	JH2	1	VκIII/A27	89	Jκ2	1	2
F9	V4-39	86	JH5b	1	VκIV/A26	98	Jκ2	0	1
F16^*	V4-59	86	JH4b	1	Vλ1	96	Jλ2	1	2

Expressed as recombinant scFv in P pastorisand in which functional glycosylation was demonstrated.

P1 is a member of V_H 3 family, but the locus has not been identified.