The effect of IL-7 on TREC levels in TOCs using thymuses of differing ages
| TOC no. . | Age of thymus . | TREC/10,000 cells . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 4 or Day 5* . | ||||||||||
| Whole . | CD3− . | CD3+ . | ||||||||
| Control . | IL-7 . | Ratio† . | Control . | IL-7 . | Ratio† . | Control . | IL-7 . | Ratio† . | ||
| 1 | Fetal 18 wk-1 | 4 738 | 6 074 | 1.3 | 4 120 | 13 561 | 3.3 | ND | ND | ND |
| 2 | 18 wk-2 | ND | ND | ND | 4 047 | 11 318 | 2.8 | ND | ND | ND |
| 3 | 19 wk | ND | ND | ND | 3 970 | 4 883 | 1.2 | 6 618 | 8 347 | 1.3 |
| 4 | 22 wk | ND | ND | ND | 1 703 | 3 885 | 2.3 | 3 310 | 5 321 | 1.6 |
| 5 | Newborn 2 d | 10 639 | 15 265 | 1.4 | 7 733 | 13 462 | 1.7 | 7 808 | 12 697 | 1.6 |
| 6 | 15 d | 9 790 | 12 333 | 1.3 | 2 080 | 5 044 | 2.4 | 7 507 | 9 751 | 1.3 |
| 7 | 3 mo | 4 682 | 6 943 | 1.5 | ND | ND | ND | ND | ND | ND |
| 8 | 4 mo | 5 175 | 6 756 | 1.3 | 2 616 | 3 232 | 1.2 | ND | ND | ND |
| 9 | 7 mo | 6 071 | 7 503 | 1.2 | 2 389 | 5 585 | 2.3 | 9 700 | 14 979 | 1.5 |
| 10 | 11 mo | 5 820 | 7 884 | 1.4 | 4 195 | 4 387 | 1.0 | 5 768 | 8 416 | 1.5 |
| 11 | Infant 3 y | 8 590 | 12 183 | 1.4 | ND | ND | ND | ND | ND | ND |
| 12 | 5.6 y | 8 297 | 10 200 | 1.2 | ND | ND | ND | ND | ND | ND |
| Mean ± SD | 1.3 ± 0.1 | 2.0 ± 0.8 | 1.5 ± 0.2 | |||||||
| TOC no. . | Age of thymus . | TREC/10,000 cells . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 4 or Day 5* . | ||||||||||
| Whole . | CD3− . | CD3+ . | ||||||||
| Control . | IL-7 . | Ratio† . | Control . | IL-7 . | Ratio† . | Control . | IL-7 . | Ratio† . | ||
| 1 | Fetal 18 wk-1 | 4 738 | 6 074 | 1.3 | 4 120 | 13 561 | 3.3 | ND | ND | ND |
| 2 | 18 wk-2 | ND | ND | ND | 4 047 | 11 318 | 2.8 | ND | ND | ND |
| 3 | 19 wk | ND | ND | ND | 3 970 | 4 883 | 1.2 | 6 618 | 8 347 | 1.3 |
| 4 | 22 wk | ND | ND | ND | 1 703 | 3 885 | 2.3 | 3 310 | 5 321 | 1.6 |
| 5 | Newborn 2 d | 10 639 | 15 265 | 1.4 | 7 733 | 13 462 | 1.7 | 7 808 | 12 697 | 1.6 |
| 6 | 15 d | 9 790 | 12 333 | 1.3 | 2 080 | 5 044 | 2.4 | 7 507 | 9 751 | 1.3 |
| 7 | 3 mo | 4 682 | 6 943 | 1.5 | ND | ND | ND | ND | ND | ND |
| 8 | 4 mo | 5 175 | 6 756 | 1.3 | 2 616 | 3 232 | 1.2 | ND | ND | ND |
| 9 | 7 mo | 6 071 | 7 503 | 1.2 | 2 389 | 5 585 | 2.3 | 9 700 | 14 979 | 1.5 |
| 10 | 11 mo | 5 820 | 7 884 | 1.4 | 4 195 | 4 387 | 1.0 | 5 768 | 8 416 | 1.5 |
| 11 | Infant 3 y | 8 590 | 12 183 | 1.4 | ND | ND | ND | ND | ND | ND |
| 12 | 5.6 y | 8 297 | 10 200 | 1.2 | ND | ND | ND | ND | ND | ND |
| Mean ± SD | 1.3 ± 0.1 | 2.0 ± 0.8 | 1.5 ± 0.2 | |||||||