NHL characteristics in 14 HIV-infected patients with MCD
| Patient . | Site of diagnosis . | Morphology . | Phenotype . | KSHV/HHV8 . | EBV . |
|---|---|---|---|---|---|
| 1 | Pleura | LC/PEL | Non-B, non-T | + PCR | + PCR |
| 2 | Pericardium | LC/PEL | Non-B, non-T | + PCR | + PCR |
| 3 | Pleura, peritoneum | LC/PEL | Non-B, non-T | + PCR | + PCR |
| 4 | Skin, BM, GI, CNS | LC | Non-B, non-T | + IHC | − EBER |
| 5 | Cerebral | LC | Non-B, non-T | + IHC | − EBER |
| 6 | Rectal | LC | Non-B, non-T | + IHC | ND |
| 7 | GI, BM | LC/anaplastic | Non-B, CD3+ (R-JH) | + IHC | − EBER |
| 8 | GI, pleura, peritoneum | LC | CD20-, μλ+, CD3− | + IHC, + PCR | − EBER, − PCR |
| 9 | Nodal | Plasmablastic | CD20+, μλ+ | + IHC | − EBER |
| 10 | Blood, spleen | Plasmablastic | ND | ND | ND |
| GI | LC/anaplastic | Non-B, CD3+, CD30+ | + IHC | − EBER | |
| 11 | Blood | Plasmablastic | ND | ND | ND |
| 12 | Blood | Plasmablastic | ND | + IHC | − EBER |
| 13 | Blood | Plasmablastic | ND | ND | ND |
| 14 | Nodal, spleen | Plasmablastic | CD20+, μλ+ | + IHC | − EBER |
| Patient . | Site of diagnosis . | Morphology . | Phenotype . | KSHV/HHV8 . | EBV . |
|---|---|---|---|---|---|
| 1 | Pleura | LC/PEL | Non-B, non-T | + PCR | + PCR |
| 2 | Pericardium | LC/PEL | Non-B, non-T | + PCR | + PCR |
| 3 | Pleura, peritoneum | LC/PEL | Non-B, non-T | + PCR | + PCR |
| 4 | Skin, BM, GI, CNS | LC | Non-B, non-T | + IHC | − EBER |
| 5 | Cerebral | LC | Non-B, non-T | + IHC | − EBER |
| 6 | Rectal | LC | Non-B, non-T | + IHC | ND |
| 7 | GI, BM | LC/anaplastic | Non-B, CD3+ (R-JH) | + IHC | − EBER |
| 8 | GI, pleura, peritoneum | LC | CD20-, μλ+, CD3− | + IHC, + PCR | − EBER, − PCR |
| 9 | Nodal | Plasmablastic | CD20+, μλ+ | + IHC | − EBER |
| 10 | Blood, spleen | Plasmablastic | ND | ND | ND |
| GI | LC/anaplastic | Non-B, CD3+, CD30+ | + IHC | − EBER | |
| 11 | Blood | Plasmablastic | ND | ND | ND |
| 12 | Blood | Plasmablastic | ND | + IHC | − EBER |
| 13 | Blood | Plasmablastic | ND | ND | ND |
| 14 | Nodal, spleen | Plasmablastic | CD20+, μλ+ | + IHC | − EBER |
BM denotes bone marrow; GI, gastrointestinal tract; CNS, central nervous system; LC, large cells; IHC, immunohistochemistry; EBER, EBV RNA in situ hybridization; and ND, not determined.