Table 5. Multivariate analyses 5-150 of... | American Society of Hematology

Table 5.

Multivariate analyses^5-150 of BFM risk groups and MRD information

Time point	Parameter^5-151	Relative estimate		Absolute estimate
Time point	Parameter^5-151	Risk ratio^5-152	P^5-153	Risk ratio^5-152	P^5-153
d 15	MRD	2.0 (0.5-7.6)	.32	4.3 (1.3-14.6)	.018
	BFM	8.3 (2.8-34.5)	< .001	8.9 (2.9-27.8)	< .001
d 33	MRD	7.0 (1.9-25.7)	< .001	7.8 (2.1-29.3)	< .001
	BFM	4.7 (1.3-16.4)	.017	4.2 (1.2-15.4)	.029
wk 12	MRD	14.9 (3.2-66.7)	< .001	26.3 (5.2-125)	< .001
	BFM	2.0 (0.5-8.4)	.36	1.2 (0.3-5.5)	.78
Combination	MRD	19.8 (3.8-104)	< .001	41.2 (7.3-234)	< .001
(d 33/wk 12)	BFM	2.4 (0.5-11.7)	.27	1.4 (0.3-6.9)	.66

Time point	Parameter^5-151	Relative estimate		Absolute estimate
Time point	Parameter^5-151	Risk ratio^5-152	P^5-153	Risk ratio^5-152	P^5-153
d 15	MRD	2.0 (0.5-7.6)	.32	4.3 (1.3-14.6)	.018
	BFM	8.3 (2.8-34.5)	< .001	8.9 (2.9-27.8)	< .001
d 33	MRD	7.0 (1.9-25.7)	< .001	7.8 (2.1-29.3)	< .001
	BFM	4.7 (1.3-16.4)	.017	4.2 (1.2-15.4)	.029
wk 12	MRD	14.9 (3.2-66.7)	< .001	26.3 (5.2-125)	< .001
	BFM	2.0 (0.5-8.4)	.36	1.2 (0.3-5.5)	.78
Combination	MRD	19.8 (3.8-104)	< .001	41.2 (7.3-234)	< .001
(d 33/wk 12)	BFM	2.4 (0.5-11.7)	.27	1.4 (0.3-6.9)	.66

F5-150

Cox regression model including BFM risk groups and MRD results; note that too few data points were available for similar calculations at weeks 22-24.

F5-151

MRD: high MRD load vs low load according to time-point-specific prognostically relevant thresholds (see “Results”); BFM: HR patients vs SR/MR patients.

F5-152

Relative risk of relapse (95% CI in parenthesis).

F5-153

P according to Wald test.

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