Characteristics of the 7 transplant recipients treated with Epstein-Barr virus-specific cytotoxic T-lymphocyte lines
| Patient . | Sex/age . | Treatment . | Interval treatment/EBV DNA positivity (y) . | Immunosuppression at time of cell harvest and infusion . | Clinical effects of CTL infusion(s) . |
|---|---|---|---|---|---|
| 1 | M/60 | Heart | 9 | CsA (1.5 mg/Kg/d) | EBV DNA fell below detectable levels |
| No evidence of rejection | |||||
| 2 | M/51 | Heart | 3 | FK506 (0.06 mg/Kg/d)* | EBV DNA fell below detectable levels |
| No evidence of rejection | |||||
| 3 | M/58 | Heart | 0.5 | CsA (4 mg/Kg/d) | EBV DNA reduced > 2 logs |
| Steroids (0.06-0.15 mg/Kg/d) | No evidence of rejection | ||||
| 4 | M/7 | Heart | 1 | CsA (10 mg/Kg/d) | EBV DNA levels still fluctuating |
| Azathioprine (0.7 mg/Kg/d) | No evidence of rejection | ||||
| 5 | F/7 | Heart | 5 | CsA (7 mg/Kg/d) | EBV DNA levels reduced > 2 logs |
| No evidence of rejection | |||||
| 6 | F/4 | Liver | 1 | CsA (4 mg/Kg/d) | EBV DNA levels still fluctuating |
| Steroids (0.4 mg/Kg every other d) | No evidence of rejection | ||||
| 7 | M/5 | Kidney | 2 | CsA (5.8 mg/Kg/d) | EBV DNA levels reduced > 2 logs |
| Steroids (0.2 mg/Kg/d) | No evidence of rejection |
| Patient . | Sex/age . | Treatment . | Interval treatment/EBV DNA positivity (y) . | Immunosuppression at time of cell harvest and infusion . | Clinical effects of CTL infusion(s) . |
|---|---|---|---|---|---|
| 1 | M/60 | Heart | 9 | CsA (1.5 mg/Kg/d) | EBV DNA fell below detectable levels |
| No evidence of rejection | |||||
| 2 | M/51 | Heart | 3 | FK506 (0.06 mg/Kg/d)* | EBV DNA fell below detectable levels |
| No evidence of rejection | |||||
| 3 | M/58 | Heart | 0.5 | CsA (4 mg/Kg/d) | EBV DNA reduced > 2 logs |
| Steroids (0.06-0.15 mg/Kg/d) | No evidence of rejection | ||||
| 4 | M/7 | Heart | 1 | CsA (10 mg/Kg/d) | EBV DNA levels still fluctuating |
| Azathioprine (0.7 mg/Kg/d) | No evidence of rejection | ||||
| 5 | F/7 | Heart | 5 | CsA (7 mg/Kg/d) | EBV DNA levels reduced > 2 logs |
| No evidence of rejection | |||||
| 6 | F/4 | Liver | 1 | CsA (4 mg/Kg/d) | EBV DNA levels still fluctuating |
| Steroids (0.4 mg/Kg every other d) | No evidence of rejection | ||||
| 7 | M/5 | Kidney | 2 | CsA (5.8 mg/Kg/d) | EBV DNA levels reduced > 2 logs |
| Steroids (0.2 mg/Kg/d) | No evidence of rejection |
EBV, Epstein-Barr virus; CTL, cytotoxic T lymphocyte; CsA, cyclosporin A.
This patient had FK506 blood levels around 9 ng/mL.