Characteristics of 137 patients treated with autologous hematopoietic cell transplantation and evaluated for hepatitis due to hepatitis B virus (HBV) reactivation, according to patients' HBV status
| Characteristic . | HBsAg positive (n = 23) . | Anti-HBs positive (n = 37) . | HBsAg or anti-HBs negative (n = 77) . | Total (n = 137) . |
|---|---|---|---|---|
| Sex: M/F | 13/10 | 21/16 | 38/39 | 72/65 |
| Median age, y (range) | 36.4 (14-56) | 40.7 (18-64) | 32.9 (1-67) | 37.0 (1-67) |
| Underlying disease | ||||
| Non-Hodgkin lymphoma | 15 | 20 | 25 | 60 |
| Breast cancer | 2 | 3 | 13 | 18 |
| Multiple myeloma | 2 | 4 | 11 | 17 |
| Hodgkin lymphoma | 2 | 3 | 6 | 11 |
| Other | 2 | 7 | 22 | 31 |
| Pretransplantation ALT | ||||
| Elevated | 3 | 0 | 3 | 6 |
| Normal | 20 | 37 | 74 | 131 |
| Hepatic events* | ||||
| Total cases of hepatitis | 13 (11) | 5 (1) | 14 (1) | 32 (13) |
| Transient hepatitis | 3 (2) | 4 | 14 (1) | 21 (3) |
| Persistent hepatitis | 10 (9) | 1 (1) | 0 | 11 (10) |
| Anicteric hepatitis | 5 (4) | 5 (1) | 11 (1) | 21 (6) |
| Icteric hepatitis | 3 (3) | 0 | 3 | 6 (3) |
| Death due to hepatic failure | 5 (4)† | 0 | 0 | 5 (4) |
| Cause of hepatitis | ||||
| HBV related | 11 | 1 | 1 | 13 |
| Sepsis | 2 | 2 | 9 | 13 |
| Unknown | 0 | 2 | 4 | 6 |
| Veno-occlusive disease | 4 | 7 | 7 | 18 |
| Characteristic . | HBsAg positive (n = 23) . | Anti-HBs positive (n = 37) . | HBsAg or anti-HBs negative (n = 77) . | Total (n = 137) . |
|---|---|---|---|---|
| Sex: M/F | 13/10 | 21/16 | 38/39 | 72/65 |
| Median age, y (range) | 36.4 (14-56) | 40.7 (18-64) | 32.9 (1-67) | 37.0 (1-67) |
| Underlying disease | ||||
| Non-Hodgkin lymphoma | 15 | 20 | 25 | 60 |
| Breast cancer | 2 | 3 | 13 | 18 |
| Multiple myeloma | 2 | 4 | 11 | 17 |
| Hodgkin lymphoma | 2 | 3 | 6 | 11 |
| Other | 2 | 7 | 22 | 31 |
| Pretransplantation ALT | ||||
| Elevated | 3 | 0 | 3 | 6 |
| Normal | 20 | 37 | 74 | 131 |
| Hepatic events* | ||||
| Total cases of hepatitis | 13 (11) | 5 (1) | 14 (1) | 32 (13) |
| Transient hepatitis | 3 (2) | 4 | 14 (1) | 21 (3) |
| Persistent hepatitis | 10 (9) | 1 (1) | 0 | 11 (10) |
| Anicteric hepatitis | 5 (4) | 5 (1) | 11 (1) | 21 (6) |
| Icteric hepatitis | 3 (3) | 0 | 3 | 6 (3) |
| Death due to hepatic failure | 5 (4)† | 0 | 0 | 5 (4) |
| Cause of hepatitis | ||||
| HBV related | 11 | 1 | 1 | 13 |
| Sepsis | 2 | 2 | 9 | 13 |
| Unknown | 0 | 2 | 4 | 6 |
| Veno-occlusive disease | 4 | 7 | 7 | 18 |