Analysis of peripheral blood and bone marrow from wild-type and C/EBPβ knockin mice
| . | % ± SD . | |
|---|---|---|
| C/ebpα+/+ . | C/ebpαβ/β . | |
| Differential cell counts | ||
| Peripheral blood | ||
| Lymphocytes | 77.7 ± 3.1 | 81.7 ± 6.5 |
| Neutrophils | 18.3 ± 2.1 | 17.3 ± 7.5 |
| Monocytes | 4.0 ± 3.6 | 1.0 ± 1.0 |
| Bone marrow | ||
| Myeloblasts & promyelocytes | 4.3 ± 0.6 | 4.7 ± 2.1 |
| Myelocytes & metamyelocytes | 8.0 ± 1.0 | 6.7 ± 2.3 |
| Neutrophils | 47.0 ± 3.5 | 51.0 ± 2.6 |
| Nucleated red blood cells | 23.0 ± 2.6 | 20.3 ± 4.5 |
| Lymphocytes | 17.3 ± 2.3 | 17.5 ± 2.4 |
| White blood cell count, 109/μL* | 7.8 | 4.4 |
| Red blood cell count, 1012/L | 9.0 | 8.8 |
| Platelet count, 109/μL* | 771.3 | 691.0 |
| . | % ± SD . | |
|---|---|---|
| C/ebpα+/+ . | C/ebpαβ/β . | |
| Differential cell counts | ||
| Peripheral blood | ||
| Lymphocytes | 77.7 ± 3.1 | 81.7 ± 6.5 |
| Neutrophils | 18.3 ± 2.1 | 17.3 ± 7.5 |
| Monocytes | 4.0 ± 3.6 | 1.0 ± 1.0 |
| Bone marrow | ||
| Myeloblasts & promyelocytes | 4.3 ± 0.6 | 4.7 ± 2.1 |
| Myelocytes & metamyelocytes | 8.0 ± 1.0 | 6.7 ± 2.3 |
| Neutrophils | 47.0 ± 3.5 | 51.0 ± 2.6 |
| Nucleated red blood cells | 23.0 ± 2.6 | 20.3 ± 4.5 |
| Lymphocytes | 17.3 ± 2.3 | 17.5 ± 2.4 |
| White blood cell count, 109/μL* | 7.8 | 4.4 |
| Red blood cell count, 1012/L | 9.0 | 8.8 |
| Platelet count, 109/μL* | 771.3 | 691.0 |
For differential counts, percentages were based on cell morphology of a total of 600 cells per genotype in peripheral blood and 700 cells per genotype in bone marrow. Each value represents the mean ± SD from 3 independent animals. Student t test showed a P value > .1 for all numbers. Total white cell, red cell, and platelet counts were determined from 2 independentC/ebpαβ/β andC/ebpα+/+ mice.
Normal reported counts21: white blood cells, 4.0-5.6 × 109/μL; red blood cells, 9.0-9.9 × 1012/L; platelets, 800-1100 × 109/μL.