Minimal responses necessary to qualify as a clinically relevant improvement
| Characteristic . | Minimal response . |
|---|---|
| Hemoglobin level | Stable increase by 1 g/dL or > 50% decrement in transfusion requirements |
| Platelet count | More than 50% increase and minimum absolute increase of 20 000/mm3 |
| Spleen size | More than 50% reduction and over 2 cm absolute reduction in linear dimension of spleen palpable below the left costal margin |
| Weight loss | Cessation of weight loss |
| Night sweats | Improvement in frequency and intensity of drenching night sweats by more than 75% |
| Fatigue | 2-point or greater improvement in mean self-reported daily fatigue level (on a modified 10-point numerical analog scale) and statement that the patient felt this improvement was meaningful |
| Fever | Resolution of fevers |
| Characteristic . | Minimal response . |
|---|---|
| Hemoglobin level | Stable increase by 1 g/dL or > 50% decrement in transfusion requirements |
| Platelet count | More than 50% increase and minimum absolute increase of 20 000/mm3 |
| Spleen size | More than 50% reduction and over 2 cm absolute reduction in linear dimension of spleen palpable below the left costal margin |
| Weight loss | Cessation of weight loss |
| Night sweats | Improvement in frequency and intensity of drenching night sweats by more than 75% |
| Fatigue | 2-point or greater improvement in mean self-reported daily fatigue level (on a modified 10-point numerical analog scale) and statement that the patient felt this improvement was meaningful |
| Fever | Resolution of fevers |
All responses had to continue for at least 4 weeks.