Results of coagulation, fibrinolysis, and platelet function studies of GSDs with platelet procoagulant deficiency
| Tests . | Affected GSD (mean of 5 dogs) . | Canine reference range . |
|---|---|---|
| Platelet count, 109/L | 220 | 170-510 |
| Mean platelet volume, fL | 11.6 | 8.4 -13.2 |
| Bleeding time, min | 3.5 | 2 -4 |
| Activated CT, s | 121 | 60 -180 |
| Whole blood CT, min | 7.8 | 6 -8 |
| Activated partial thromboplastin time, sec | 11.8 | 10 -17 |
| PT, sec | 14.0 | 14 -18 |
| Thrombin CT, sec | 6.8 | 5 -9 |
| Russell viper venom time, sec | 21.0 | 19 -23 |
| Fibrinogen, g/L | 3.6 | 1.5 -4.8 |
| Factor II, % | 107 | 50 -150 |
| Antithrombin, % | 97 | 70 -125 |
| Protein C, % | 111 | 60 -160 |
| Plasminogen, % | 94 | 60 -170 |
| Antiplasmin | 106 | 65 -115 |
| FDP, mg/L | < 5 | < 5 |
| D-dimer, μg/L | < 250 | < 250 |
| VWF: antigen, % | 87 | 70 -180 |
| VWF: Rcof, % | 93 | 50 -170 |
| Platelet aggregation: | ||
| Adenosine diphosphate (5 μM), % | 77 | > 5 |
| Adenosine diphosphate (10 μM), % | 90 | > 60 |
| Collagen (12 ug/mL), % | 63 | > 60 |
| Collagen (24 ug/mL), % | 95 | > 60 |
| Platelet secretion, μM ATP release per 1011 platelets | (mean of 3 dogs) | |
| Adenosine diphosphate (10 μM), μM | 0.07 | 0.06 -0.10 |
| Collagen (12 ug/mL), μM | 0.9 | 0.41 -1.05 |
| Collagen (24 ug/mL), μM | 1.01 | 0.68 -1.43 |
| Bovine α-thrombin (1 U/mL), μM | 1.35 | 1.21 -1.63 |
| Tests . | Affected GSD (mean of 5 dogs) . | Canine reference range . |
|---|---|---|
| Platelet count, 109/L | 220 | 170-510 |
| Mean platelet volume, fL | 11.6 | 8.4 -13.2 |
| Bleeding time, min | 3.5 | 2 -4 |
| Activated CT, s | 121 | 60 -180 |
| Whole blood CT, min | 7.8 | 6 -8 |
| Activated partial thromboplastin time, sec | 11.8 | 10 -17 |
| PT, sec | 14.0 | 14 -18 |
| Thrombin CT, sec | 6.8 | 5 -9 |
| Russell viper venom time, sec | 21.0 | 19 -23 |
| Fibrinogen, g/L | 3.6 | 1.5 -4.8 |
| Factor II, % | 107 | 50 -150 |
| Antithrombin, % | 97 | 70 -125 |
| Protein C, % | 111 | 60 -160 |
| Plasminogen, % | 94 | 60 -170 |
| Antiplasmin | 106 | 65 -115 |
| FDP, mg/L | < 5 | < 5 |
| D-dimer, μg/L | < 250 | < 250 |
| VWF: antigen, % | 87 | 70 -180 |
| VWF: Rcof, % | 93 | 50 -170 |
| Platelet aggregation: | ||
| Adenosine diphosphate (5 μM), % | 77 | > 5 |
| Adenosine diphosphate (10 μM), % | 90 | > 60 |
| Collagen (12 ug/mL), % | 63 | > 60 |
| Collagen (24 ug/mL), % | 95 | > 60 |
| Platelet secretion, μM ATP release per 1011 platelets | (mean of 3 dogs) | |
| Adenosine diphosphate (10 μM), μM | 0.07 | 0.06 -0.10 |
| Collagen (12 ug/mL), μM | 0.9 | 0.41 -1.05 |
| Collagen (24 ug/mL), μM | 1.01 | 0.68 -1.43 |
| Bovine α-thrombin (1 U/mL), μM | 1.35 | 1.21 -1.63 |