Outcome and patient characteristics according to age at start of prophylactic treatment
| Age at start of prophylaxis, y . | Early: younger than 4 . | Late: 4 to 7 y . | Very late: 8 y or older . |
|---|---|---|---|
| Patients | |||
| No. | 16 | 34 | 26 |
| Age at last Pettersson score, y | 16.4 (14.2-20.4) | 19.7 (16.6-24.4) | 20.4 (15.7-27.6) |
| Age at first joint bleed, y | 1.3 (0.8-2.0) | 2.2 (1.2-2.7) | 3.1 (1.7-3.7) |
| Treatment | |||
| Age at start of prophylaxis, y | 2.4 (1.4-3.1) | 5.4 (4.7-6.9) | 10.0 (8.8-12.4) |
| Lag time, y | 0.4 (0.0-1.6) | 3.2 (1.6-4.5) | 7.6 (6.4-10.5) |
| No. of joint bleeds until prophylaxis | 3.5 (1-11) | 17 (9-38) | 100 (60-132) |
| Outcome | |||
| Last Pettersson score (maximum 78) | 2 (0-6.5) | 8 (2-16) | 11.5 (3-23) |
| Pts with last Pettersson above 0, % | 50 | 79 | 77 |
| Clinical score (maximum 90)* | 1 (0-2) | 3 (1-5) | 5 (2-8) |
| Pts with clinical score above 0, % | 56 | 76 | 81 |
| Age at start of prophylaxis, y . | Early: younger than 4 . | Late: 4 to 7 y . | Very late: 8 y or older . |
|---|---|---|---|
| Patients | |||
| No. | 16 | 34 | 26 |
| Age at last Pettersson score, y | 16.4 (14.2-20.4) | 19.7 (16.6-24.4) | 20.4 (15.7-27.6) |
| Age at first joint bleed, y | 1.3 (0.8-2.0) | 2.2 (1.2-2.7) | 3.1 (1.7-3.7) |
| Treatment | |||
| Age at start of prophylaxis, y | 2.4 (1.4-3.1) | 5.4 (4.7-6.9) | 10.0 (8.8-12.4) |
| Lag time, y | 0.4 (0.0-1.6) | 3.2 (1.6-4.5) | 7.6 (6.4-10.5) |
| No. of joint bleeds until prophylaxis | 3.5 (1-11) | 17 (9-38) | 100 (60-132) |
| Outcome | |||
| Last Pettersson score (maximum 78) | 2 (0-6.5) | 8 (2-16) | 11.5 (3-23) |
| Pts with last Pettersson above 0, % | 50 | 79 | 77 |
| Clinical score (maximum 90)* | 1 (0-2) | 3 (1-5) | 5 (2-8) |
| Pts with clinical score above 0, % | 56 | 76 | 81 |
Values are numbers or medians (IQR: 25th and 75th percentiles).
The clinical score was assessed within 1 year of the last Pettersson score.