Intergroup comparison of the changes in coagulation parameters in groups A, B, and C
| . | A (UFH) N = 375 . | B (reviparin bid) N = 388 . | C (reviparin od) N = 374 . | P . | ||
|---|---|---|---|---|---|---|
| A vs B . | A vs C . | B vs C . | ||||
| First wk—baseline | ||||||
| aPTT (s) | 15.3 (− .20, 34.9) | 14.3 (0.40, 27.3) | − 2.6 (− 17, 7.60) | .22 | < .001 | < .001 |
| Antifactor Xa (U/mL) | 0.06 (− .11, 0.27) | 0.26 (0.04, 0.51) | 0.19 (0.01, 0.51) | < .001 | < .001 | .24 |
| Fibrinogen (g/L) | 0.52 (− .05, 1.14) | 0.43 (− .11, 0.91) | 0.10 (− .29, 0.54) | .17 | < .001 | < .001 |
| AT (% of normal) | − 10 (− 29, 6.00) | 3.00 (− 10, 22.0) | 5.00 (− 15, 22.5) | < .001 | < .001 | .85 |
| TAT complexes (ng/mL) | − 1.4 (− 4.5, − .10) | − 1.8 (− 5.7, − .14) | − .82 (− 4.2, 0.68) | .10 | .07 | < .001 |
| Prothrombin F1 + 2 (ng/mL) | − .67 (− 1.6, − .10) | − .84 (− 1.8, − .32) | − .23 (− .77, 0.23) | .005 | < .001 | < .001 |
| ETP-ext (nM/min) | − 264 (− 462, 29.1) | − 330 (− 496, − 123) | 2.97 (− 115, 110) | .008 | < .001 | < .001 |
| D-dimer (ng/mL) | − 98 (− 332, 16.7) | − 151 (− 447, − 18) | − 99 (− 351, 0.00) | .003 | .36 | .03 |
| TFPI level (U/mL) | − 13 (− 74, 37.0) | 11.0 (− 41, 77.5) | 9.90 (− 30, 78.3) | < .001 | < .001 | .51 |
| TAFI level (μg/mL)] | − .60 (− 1.0, − .10) | − .80 (− 1.1, − .30) | − .80 (− 1.3, − .30) | .006 | < .001 | .28 |
| Third wk—First wk | ||||||
| Fibrinogen (g/L) | − .40 (− 1.2, 0.47) | − .20 (− .91, 0.32) | − .58 (− 1.1, 0.10) | .20 | .03 | < .001 |
| TAT complexes (ng/mL) | − .65 (− 2.1, 0.18) | − .42 (− 1.5, 0.12) | − .50 (− 2.5, 0.43) | .11 | .47 | .56 |
| Prothrombin F1 + 2 (ng/mL) | − .43 (− 1.0, − .09) | − .30 (− .70, − .07) | − .12 (− .42, 0.19) | .03 | < .001 | < .001 |
| ETP-ext (nM/min) | − 69 (− 220, 67.7) | − 35 (− 149, 77.1) | − 35 (− 139, 43.8) | .009 | .010 | .29 |
| D-dimer (ng/mL) | − 185 (− 397, − 55) | − 160 (− 315, − 46) | − 186 (− 341, − 63) | .08 | 1.00 | .07 |
| TFPI level (U/mL) | − 19 (− 81, 13.4) | − 28 (− 79, 5.80) | − 12 (− 62, 29.1) | .20 | .05 | .001 |
| TAFI level (μg/mL) | 0.40 (0.00, 0.70) | 0.40 (0.10, 0.70) | − .20 (− .50, 0.20) | .85 | < .001 | < .001 |
| . | A (UFH) N = 375 . | B (reviparin bid) N = 388 . | C (reviparin od) N = 374 . | P . | ||
|---|---|---|---|---|---|---|
| A vs B . | A vs C . | B vs C . | ||||
| First wk—baseline | ||||||
| aPTT (s) | 15.3 (− .20, 34.9) | 14.3 (0.40, 27.3) | − 2.6 (− 17, 7.60) | .22 | < .001 | < .001 |
| Antifactor Xa (U/mL) | 0.06 (− .11, 0.27) | 0.26 (0.04, 0.51) | 0.19 (0.01, 0.51) | < .001 | < .001 | .24 |
| Fibrinogen (g/L) | 0.52 (− .05, 1.14) | 0.43 (− .11, 0.91) | 0.10 (− .29, 0.54) | .17 | < .001 | < .001 |
| AT (% of normal) | − 10 (− 29, 6.00) | 3.00 (− 10, 22.0) | 5.00 (− 15, 22.5) | < .001 | < .001 | .85 |
| TAT complexes (ng/mL) | − 1.4 (− 4.5, − .10) | − 1.8 (− 5.7, − .14) | − .82 (− 4.2, 0.68) | .10 | .07 | < .001 |
| Prothrombin F1 + 2 (ng/mL) | − .67 (− 1.6, − .10) | − .84 (− 1.8, − .32) | − .23 (− .77, 0.23) | .005 | < .001 | < .001 |
| ETP-ext (nM/min) | − 264 (− 462, 29.1) | − 330 (− 496, − 123) | 2.97 (− 115, 110) | .008 | < .001 | < .001 |
| D-dimer (ng/mL) | − 98 (− 332, 16.7) | − 151 (− 447, − 18) | − 99 (− 351, 0.00) | .003 | .36 | .03 |
| TFPI level (U/mL) | − 13 (− 74, 37.0) | 11.0 (− 41, 77.5) | 9.90 (− 30, 78.3) | < .001 | < .001 | .51 |
| TAFI level (μg/mL)] | − .60 (− 1.0, − .10) | − .80 (− 1.1, − .30) | − .80 (− 1.3, − .30) | .006 | < .001 | .28 |
| Third wk—First wk | ||||||
| Fibrinogen (g/L) | − .40 (− 1.2, 0.47) | − .20 (− .91, 0.32) | − .58 (− 1.1, 0.10) | .20 | .03 | < .001 |
| TAT complexes (ng/mL) | − .65 (− 2.1, 0.18) | − .42 (− 1.5, 0.12) | − .50 (− 2.5, 0.43) | .11 | .47 | .56 |
| Prothrombin F1 + 2 (ng/mL) | − .43 (− 1.0, − .09) | − .30 (− .70, − .07) | − .12 (− .42, 0.19) | .03 | < .001 | < .001 |
| ETP-ext (nM/min) | − 69 (− 220, 67.7) | − 35 (− 149, 77.1) | − 35 (− 139, 43.8) | .009 | .010 | .29 |
| D-dimer (ng/mL) | − 185 (− 397, − 55) | − 160 (− 315, − 46) | − 186 (− 341, − 63) | .08 | 1.00 | .07 |
| TFPI level (U/mL) | − 19 (− 81, 13.4) | − 28 (− 79, 5.80) | − 12 (− 62, 29.1) | .20 | .05 | .001 |
| TAFI level (μg/mL) | 0.40 (0.00, 0.70) | 0.40 (0.10, 0.70) | − .20 (− .50, 0.20) | .85 | < .001 | < .001 |
Median values with first and third quartiles shown.