Correlations between chromosomal 14q32 abnormalities, β2-microglobulin serum levels, del(13) and prognostic presentation
| . | All MM patients (%) . | Patients lacking 14q32 abnormality . | Patients with t(11;14) . | Patients with t(4;14) . | Patients with t(14;16) . | Patients with other 14q32 abnormalities . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | ||
| del(13) | 286/669 (43) | 39/176 (22) | < 10−9 | 42/105 (40) | NS | 58/68 (85) | < 10−8 | 13/14 (93) | < .001 | 121/290 (42) | NS |
| β2-microglobulin greater than 3 mg/L | 382/669 (57) | 81/176 (54) | < .001 | 54/105 (51) | NS | 63/68 (93) | < 10−9 | 11/14 (79) | NS | 157/290 (54) | NS |
| β13 = 0 | 195/669 (29) | 82/176 (47) | < 10−8 | 35/105 (33) | NS | 1/68 (1) | < 10−6 | 0/14 (0) | .033 | 77/290 (27) | NS |
| β13 = 1 | 305/669 (46) | 71/176 (40) | NS | 43/105 (41) | NS | 24/68 (35) | NS | 4/14 (29) | NS | 158/290 (54) | < .0001 |
| β13 = 2 | 169/669 (25) | 23/176 (13) | < .0001 | 27/105 (26) | NS | 43/68 (64) | < 10−9 | 10/14 (71) | < .001 | 55/290 (19) | .001 |
| . | All MM patients (%) . | Patients lacking 14q32 abnormality . | Patients with t(11;14) . | Patients with t(4;14) . | Patients with t(14;16) . | Patients with other 14q32 abnormalities . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | ||
| del(13) | 286/669 (43) | 39/176 (22) | < 10−9 | 42/105 (40) | NS | 58/68 (85) | < 10−8 | 13/14 (93) | < .001 | 121/290 (42) | NS |
| β2-microglobulin greater than 3 mg/L | 382/669 (57) | 81/176 (54) | < .001 | 54/105 (51) | NS | 63/68 (93) | < 10−9 | 11/14 (79) | NS | 157/290 (54) | NS |
| β13 = 0 | 195/669 (29) | 82/176 (47) | < 10−8 | 35/105 (33) | NS | 1/68 (1) | < 10−6 | 0/14 (0) | .033 | 77/290 (27) | NS |
| β13 = 1 | 305/669 (46) | 71/176 (40) | NS | 43/105 (41) | NS | 24/68 (35) | NS | 4/14 (29) | NS | 158/290 (54) | < .0001 |
| β13 = 2 | 169/669 (25) | 23/176 (13) | < .0001 | 27/105 (26) | NS | 43/68 (64) | < 10−9 | 10/14 (71) | < .001 | 55/290 (19) | .001 |
β13 indicates staging for β2 microglobulin/del(13); 0 indicates low β2-microglobulin and no del(13); 1, high β2-microglobulin or del(13); and 2, high β2-microglobulin and del(13).
All correlations were calculated for differences with other patients.