Table 2. Correlations between... | American Society of Hematology

Table 2.

Correlations between chromosomal abnormalities and immunoglobulin types and light-chain subtypes in patients with multiple myeloma

Chromosomal abnormalities	Overall MM (n = 669) (%)	IgG MM (n = 399) (%)	IgA MM (n = 175)		BJ MM (n = 95)		Kappa MM (n = 455) (%)	Lambda MM (n = 214)
Chromosomal abnormalities	Overall MM (n = 669) (%)	IgG MM (n = 399) (%)	No. (%)	P^*	No. (%)	P^*	Kappa MM (n = 455) (%)	No. (%)	P^†
14q32 rearrangements^‡	477/653 (73)	269/393 (68)	133/170 (78)	.024	75/90 (83)	.007	325/450 (72)	152/203 (75)	NS (.49)
t(11;14)	105/669 (16)	58/399 (15)	18/175 (10)	NS	29/95 (31)	< .0005	65/455 (14)	40/214 (19)	NS (.1)
t(4;14)	68/669 (10)	30/399 (8)	34/175 (19)	< .0001	4/95 (4)	NS	49/455 (11)	19/214 (9)	NS (.69)
del(13)	290/669 (43)	159/399 (40)	85/175 (49)	NS	46/95 (48)	NS	181/455 (40)	109/214 (51)	.026

Chromosomal abnormalities	Overall MM (n = 669) (%)	IgG MM (n = 399) (%)	IgA MM (n = 175)		BJ MM (n = 95)		Kappa MM (n = 455) (%)	Lambda MM (n = 214)
Chromosomal abnormalities	Overall MM (n = 669) (%)	IgG MM (n = 399) (%)	No. (%)	P^*	No. (%)	P^*	Kappa MM (n = 455) (%)	No. (%)	P^†
14q32 rearrangements^‡	477/653 (73)	269/393 (68)	133/170 (78)	.024	75/90 (83)	.007	325/450 (72)	152/203 (75)	NS (.49)
t(11;14)	105/669 (16)	58/399 (15)	18/175 (10)	NS	29/95 (31)	< .0005	65/455 (14)	40/214 (19)	NS (.1)
t(4;14)	68/669 (10)	30/399 (8)	34/175 (19)	< .0001	4/95 (4)	NS	49/455 (11)	19/214 (9)	NS (.69)
del(13)	290/669 (43)	159/399 (40)	85/175 (49)	NS	46/95 (48)	NS	181/455 (40)	109/214 (51)	.026

BJ indicates Bence Jones only. See Table 1 for other abbreviations.

These P values are for difference with IgG MM.

These P values are for difference with Kappa MM.

Patients with monosomy 14 were considered noninformative for this item and were excluded from analysis.