Hematological data for wild-type and mutant mice
| Genotype . | Hematocrit, % . | MCV, fL . | Reticulocytes, % . | MCH concentration, g/dL . | MCH, pg . |
|---|---|---|---|---|---|
| Age 28 to 35 d | |||||
| WT (n = 5) | 52.9 ± 1.5 | 57.6 ± 0.5 | 4.3 ± 0.6 | 29.2 ± 0.69 | 15.8 ± 0.6 |
| ApoE−/− (n = 8) | 52.5 ± 2.1 | 62.6 ± 3.6 | 2.8 ± 1.2 | 27.3 ± 1.0 | 16.6 ± 0.5 |
| SR-BI−/− (n = 14) | 50.7 ± 2.7 | 62.5 ± 4.2 | 11.9 ± 4.0 | 28 ± 1.1 | 16.1 ± 0.6 |
| SR-BI−/−/apoE−/−(n = 6) | 34.2 ± 1.7 | 84.1 ± 4.1 | 100 | 17.5 ± 1.3 | 15.0 ± 0.5 |
| 3 mo on normal or cholesterol-supplemented diet; age, 4 mo | |||||
| WT, normal diet (n = 5) | 54.0 ± 4 | 50.0 ± 1.5 | 2.5 ± 0.2 | 30.8 ± 1.2 | 15.3 ± 0.3 |
| WT, cholesterol diet (n = 5) | 55.5 ± 0.5 | 51.1 ± 2 | 2.4 ± 0.3 | 29.1 ± 1.9 | 14.8 ± 0.7 |
| SR-BI−/−, normal diet (n = 5) | 47.3 ± 3 | 54.8 ± 3 | 6.2 ± 1.0 | 28.4 ± 1.4 | 15.5 ± 0.5 |
| SR-BI−/−, cholesterol diet (n = 7) | 39.6 ± 2 | 63.3 ± 2 | 18.5 ± 3.0 | 27 ± 1.0 | 15.9 ± 0.6 |
| Genotype . | Hematocrit, % . | MCV, fL . | Reticulocytes, % . | MCH concentration, g/dL . | MCH, pg . |
|---|---|---|---|---|---|
| Age 28 to 35 d | |||||
| WT (n = 5) | 52.9 ± 1.5 | 57.6 ± 0.5 | 4.3 ± 0.6 | 29.2 ± 0.69 | 15.8 ± 0.6 |
| ApoE−/− (n = 8) | 52.5 ± 2.1 | 62.6 ± 3.6 | 2.8 ± 1.2 | 27.3 ± 1.0 | 16.6 ± 0.5 |
| SR-BI−/− (n = 14) | 50.7 ± 2.7 | 62.5 ± 4.2 | 11.9 ± 4.0 | 28 ± 1.1 | 16.1 ± 0.6 |
| SR-BI−/−/apoE−/−(n = 6) | 34.2 ± 1.7 | 84.1 ± 4.1 | 100 | 17.5 ± 1.3 | 15.0 ± 0.5 |
| 3 mo on normal or cholesterol-supplemented diet; age, 4 mo | |||||
| WT, normal diet (n = 5) | 54.0 ± 4 | 50.0 ± 1.5 | 2.5 ± 0.2 | 30.8 ± 1.2 | 15.3 ± 0.3 |
| WT, cholesterol diet (n = 5) | 55.5 ± 0.5 | 51.1 ± 2 | 2.4 ± 0.3 | 29.1 ± 1.9 | 14.8 ± 0.7 |
| SR-BI−/−, normal diet (n = 5) | 47.3 ± 3 | 54.8 ± 3 | 6.2 ± 1.0 | 28.4 ± 1.4 | 15.5 ± 0.5 |
| SR-BI−/−, cholesterol diet (n = 7) | 39.6 ± 2 | 63.3 ± 2 | 18.5 ± 3.0 | 27 ± 1.0 | 15.9 ± 0.6 |
Values are given with SDs. The P values for significantly different measurements are given in the text. Normal mouse reticulocyte counts range from 2% to 6% early in life and decrease slightly as the mice age.
MCV indicates mean corpuscular volume; MCH, mean corpuscular hemoglobin; WT, wild-type; apoE, apolipoprotein E.