Mutation analysis in splenic marginal zone lymphoma cases
| Case . | Gene . | Identity (%) . | N . | Observed R/S . | Expected R/S . | p CDR . | p FR . | ||
|---|---|---|---|---|---|---|---|---|---|
| CDR . | FR . | CDR . | FR . | ||||||
| 5 | VH1-2 | 97.21 | 6 | 1/1 | 1/3 | 1.44 | 3.06 | .365 | .086 |
| 5 | VH3-8 | 96.41 | 7 | 1/0 | 5/1 | 1.68 | 3.57 | .323 | .173 |
| 33 | VH1-2 | 93.4 | 15 | 3/3 | 3/6 | 3.6 | 7.65 | .23 | .01 |
| 365 | VH1-2 | 95.96 | 9 | 2/0 | 3/4 | 2.16 | 4.59 | .303 | .154 |
| 374 | VH1-2 | 97.8 | 5 | 1/0 | 3/1 | 1.2 | 2.55 | .40 | .31 |
| 376 | VH1-2 | 96.4 | 10 | 2/1 | 3/4 | 2.4 | 5.1 | .28 | .10 |
| 247 | VH1-69 | 92.38 | 17 | 3/1 | 9/4 | 4.08 | 8.67 | .201 | .188 |
| 85 | VH4-34 | 96.35 | 8 | 2/0 | 6/0 | 1.92 | 4.08 | .310 | .118 |
| 293 | VH1-2 | 96.41 | 8 | 1/2 | 4/1 | 1.92 | 4.08 | .281 | .273 |
| 380 | VH1-2 | 97.1 | 7 | 3/1 | 1/2 | 1.68 | 3.57 | .16 | .04 |
| 377 | VH3-30 | 90.0 | 22 | 9/4 | 5/4 | 5.28 | 11.22 | .037 | .004 |
| 367 | VH3-23 | 97.8 | 5 | 3/1 | 1/0 | 1.2 | 2.55 | .07 | .14 |
| 371 | VH3-7 | 88.0 | 27 | 10/5 | 8/4 | 6.48 | 13.77 | .05 | .01 |
| 222 | VH3-74 | 90.62 | 21 | 3/6 | 9/3 | 5.04 | 10.71 | .131 | .131 |
| 225 | VH3-30 | 95.98 | 7 | 1/1 | 4/1 | 1.68 | 3.57 | .323 | .278 |
| 225 | VH3-30 | 95.98 | 7 | 1/1 | 4/1 | 1.68 | 3.57 | .323 | .278 |
| 12 | VH4-34 | 96.35 | 8 | 1/0 | 5/2 | 1.92 | 4.08 | .281 | .227 |
| 253 | VH4-34 | 92.76 | 16 | 7/1 | 7/1 | 3.84 | 8.16 | .044 | .167 |
| 202 | VH4-34 | 89.54 | 23 | 7/1 | 6/10 | 5.52 | 11.73 | .139 | .003 |
| 364 | VH6-1 | — | 13 | 1/4 | 6/2 | 3.12 | 6.63 | .11 | .20 |
| Case . | Gene . | Identity (%) . | N . | Observed R/S . | Expected R/S . | p CDR . | p FR . | ||
|---|---|---|---|---|---|---|---|---|---|
| CDR . | FR . | CDR . | FR . | ||||||
| 5 | VH1-2 | 97.21 | 6 | 1/1 | 1/3 | 1.44 | 3.06 | .365 | .086 |
| 5 | VH3-8 | 96.41 | 7 | 1/0 | 5/1 | 1.68 | 3.57 | .323 | .173 |
| 33 | VH1-2 | 93.4 | 15 | 3/3 | 3/6 | 3.6 | 7.65 | .23 | .01 |
| 365 | VH1-2 | 95.96 | 9 | 2/0 | 3/4 | 2.16 | 4.59 | .303 | .154 |
| 374 | VH1-2 | 97.8 | 5 | 1/0 | 3/1 | 1.2 | 2.55 | .40 | .31 |
| 376 | VH1-2 | 96.4 | 10 | 2/1 | 3/4 | 2.4 | 5.1 | .28 | .10 |
| 247 | VH1-69 | 92.38 | 17 | 3/1 | 9/4 | 4.08 | 8.67 | .201 | .188 |
| 85 | VH4-34 | 96.35 | 8 | 2/0 | 6/0 | 1.92 | 4.08 | .310 | .118 |
| 293 | VH1-2 | 96.41 | 8 | 1/2 | 4/1 | 1.92 | 4.08 | .281 | .273 |
| 380 | VH1-2 | 97.1 | 7 | 3/1 | 1/2 | 1.68 | 3.57 | .16 | .04 |
| 377 | VH3-30 | 90.0 | 22 | 9/4 | 5/4 | 5.28 | 11.22 | .037 | .004 |
| 367 | VH3-23 | 97.8 | 5 | 3/1 | 1/0 | 1.2 | 2.55 | .07 | .14 |
| 371 | VH3-7 | 88.0 | 27 | 10/5 | 8/4 | 6.48 | 13.77 | .05 | .01 |
| 222 | VH3-74 | 90.62 | 21 | 3/6 | 9/3 | 5.04 | 10.71 | .131 | .131 |
| 225 | VH3-30 | 95.98 | 7 | 1/1 | 4/1 | 1.68 | 3.57 | .323 | .278 |
| 225 | VH3-30 | 95.98 | 7 | 1/1 | 4/1 | 1.68 | 3.57 | .323 | .278 |
| 12 | VH4-34 | 96.35 | 8 | 1/0 | 5/2 | 1.92 | 4.08 | .281 | .227 |
| 253 | VH4-34 | 92.76 | 16 | 7/1 | 7/1 | 3.84 | 8.16 | .044 | .167 |
| 202 | VH4-34 | 89.54 | 23 | 7/1 | 6/10 | 5.52 | 11.73 | .139 | .003 |
| 364 | VH6-1 | — | 13 | 1/4 | 6/2 | 3.12 | 6.63 | .11 | .20 |
R, replacement mutation; S, silent mutation; N, total number of mutations observed; CDR, complementarity-determining region; FR, framework region; VH, variable region of the heavy chain.