Splenic marginal zone lymphoma data in unmutated immunoglobulin heavy chain gene cases
| Case . | VH gene . | ID (%) . | Karyotype . | LOH 7q . | CD38 . | IgD . | Months . | Progression . | Follow-up . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | VH1-2 | 99.55 | 46XX, t(1;15)(p11;q11), del(8)(q12), del(18q),del1(14q), del(7)(q22q33) | Yes | + | + | 53 | Yes | AWD |
| 4 | VH1-2 | 98.21 | 46XX,del(1)(q32)[7], 46XX[13] | Yes | + | 72 | Yes | AWD | |
| 10 | VH1-2 | 98.65 | No | − | + | 77 | No | AWD | |
| 13 | VH1-2 | 100 | 85-90XXY, 1q-, t(1;2), 3p-, der(4), 5p-, 6q-, 9p-, dup(10q), der(14q),der(17q), der(20q) | + | + | 17 | Yes | DOD | |
| 220 | VH1-2 | 100 | 47XY, del(7q?), t(1;2)(q32q32), add17p13 | Yes | + | + | 3 | Yes | DOD |
| 221 | VH1-2 | 99.1 | 46XX, del(7)(q21q31) | Yes | − | + | 22 | Yes | DOD |
| 238 | VH1-2 | 98.2 | + | 3 | Yes | DOD | |||
| 254 | VH1-2 | 98.21 | 46XY, del(7)(q31qter) | Yes | − | + | 30 | No | AWD |
| 265 | VH1-2 | 98.21 | 46XX | No | − | ± | 4 | Yes | DOD |
| 375 | VH1-2 | 99.1 | − | + | 26 | No | AWD | ||
| 373 | VH3-30 | 100 | + | + | 10 | Yes | DOD | ||
| VH1-18 | 99.5 | ||||||||
| 379 | VH3-33 | 100 | + | + | 14 | No | AWD | ||
| 74 | VH4-39 | 100 | 44XY,−20,−21, t(1;3)(q2q2),del(8)(q22qter), | Yes | + | + | 57 | Yes | DOD |
| VH3-79 | 100 | −7,+der, t(7;17)(p12p12), del7(7)(q32) | |||||||
| 2 | VH4-34 | 100 | 46XY | No | + | + | 80 | Yes | DOD |
| 368 | VH4-4 | 100 | 46XX, del(7)(q32) | 9 | No | AWD | |||
| 372 | VH4-34 | 100 | 46XY, del(7)(q32) | 16 | No | AWD | |||
| 162 | VH2 | 98.9 | − | + | 34 | Yes | DOD |
| Case . | VH gene . | ID (%) . | Karyotype . | LOH 7q . | CD38 . | IgD . | Months . | Progression . | Follow-up . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | VH1-2 | 99.55 | 46XX, t(1;15)(p11;q11), del(8)(q12), del(18q),del1(14q), del(7)(q22q33) | Yes | + | + | 53 | Yes | AWD |
| 4 | VH1-2 | 98.21 | 46XX,del(1)(q32)[7], 46XX[13] | Yes | + | 72 | Yes | AWD | |
| 10 | VH1-2 | 98.65 | No | − | + | 77 | No | AWD | |
| 13 | VH1-2 | 100 | 85-90XXY, 1q-, t(1;2), 3p-, der(4), 5p-, 6q-, 9p-, dup(10q), der(14q),der(17q), der(20q) | + | + | 17 | Yes | DOD | |
| 220 | VH1-2 | 100 | 47XY, del(7q?), t(1;2)(q32q32), add17p13 | Yes | + | + | 3 | Yes | DOD |
| 221 | VH1-2 | 99.1 | 46XX, del(7)(q21q31) | Yes | − | + | 22 | Yes | DOD |
| 238 | VH1-2 | 98.2 | + | 3 | Yes | DOD | |||
| 254 | VH1-2 | 98.21 | 46XY, del(7)(q31qter) | Yes | − | + | 30 | No | AWD |
| 265 | VH1-2 | 98.21 | 46XX | No | − | ± | 4 | Yes | DOD |
| 375 | VH1-2 | 99.1 | − | + | 26 | No | AWD | ||
| 373 | VH3-30 | 100 | + | + | 10 | Yes | DOD | ||
| VH1-18 | 99.5 | ||||||||
| 379 | VH3-33 | 100 | + | + | 14 | No | AWD | ||
| 74 | VH4-39 | 100 | 44XY,−20,−21, t(1;3)(q2q2),del(8)(q22qter), | Yes | + | + | 57 | Yes | DOD |
| VH3-79 | 100 | −7,+der, t(7;17)(p12p12), del7(7)(q32) | |||||||
| 2 | VH4-34 | 100 | 46XY | No | + | + | 80 | Yes | DOD |
| 368 | VH4-4 | 100 | 46XX, del(7)(q32) | 9 | No | AWD | |||
| 372 | VH4-34 | 100 | 46XY, del(7)(q32) | 16 | No | AWD | |||
| 162 | VH2 | 98.9 | − | + | 34 | Yes | DOD |
VH indicates variable region of the heavy chain; ID, identity frequency; LOH, loss of heterozygosity; IgD, immunoglobulin D; Months, follow-up months; Progression, clinical progression; AWD, alive with disease; DOD, died of disease.