Table 1.

Distribution of Thr325Ile polymorphism of the TAFI gene and association with plasma TAFI Ag levels in individuals with MI and controls

Control (n = 571)MI (n = 525)
No. individuals (%)TAFI Ag*,† mean (SD)No. individuals (%)TAFI Ag*,† mean (SD)
Thr/Thr 267  (47) 116.3  (55.4) 260  (50) 108.0  (46.9)  
Thr/Ile 255  (45) 77.6  (32.2) 216  (41) 74.9  (33.4) 
Ile/Ile 49  (8) 44.4  (24.5) 49  (9) 42.6  (23.7) 
Control (n = 571)MI (n = 525)
No. individuals (%)TAFI Ag*,† mean (SD)No. individuals (%)TAFI Ag*,† mean (SD)
Thr/Thr 267  (47) 116.3  (55.4) 260  (50) 108.0  (46.9)  
Thr/Ile 255  (45) 77.6  (32.2) 216  (41) 74.9  (33.4) 
Ile/Ile 49  (8) 44.4  (24.5) 49  (9) 42.6  (23.7) 

P = .42 for difference in MI cases and controls by Thr325Ile, from conditional logistic regression.

*

Expressed as percentage of pooled plasma from 30 healthy volunteers.

†

P < .00005 for relation between plasma TAFI Ag levels and TAFI genotypes, by ANOVA.

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