Table 2. Flow-cytometric analysis of... | American Society of Hematology

Table 2.

Flow-cytometric analysis of bone marrow mononuclear cells

	Untreated RA patients^*	Treated RA patients^†	Total RA patients^*	Healthy controls
BMMC fraction
% CD34⁺cells	1.18 ± 0.44^‡	1.49 ± 1.06	1.42 ± 0.94	2.13 ± 1.02
Median (range)	1.30 (0.55-1.80)	1.20 (0.40-4.10)	1.20 (0.40-4.10)	1.90 (0.70-4.80)
n	6	20	26	37
P^2-153	.0142	.0091	.0016
P^2-155	.9519
% CD34⁺/CD38⁺ cells	0.92 ± 0.32	1.04 ± 0.76	1.03 ± 0.69	1.69 ± 0.89
Median (range)	1.00 (0.46-1.30)	1.84 (0.20-3.00)	0.92 (0.20-3.00)	1.60 (0.30-4.50)
n	6	20	26	37
P^2-153	.0439	.0038	.0017
P^2-155	.8550
% CD34⁺/CD38⁻ cells	0.26 ± 0.14	0.41 ± 0.34	0.36 ± 0.31	0.44 ± 0.28
Median (range)	0.25 (0.09-0.50)	0.30 (0.10-1.40)	0.25 (0.09-1.40)	0.38 (0.10-1.18)
n	6	20	26	37
P^2-153	.1188	.4871	.1890
P^2-155	.2726
CD34⁺cell fraction
% Fas⁺cells	15.78 ± 6.39	14.48 ± 10.33	15.02 ± 9.62	8.38 ± 3.68
Median (range)	14.48 (8.90-25.50)	9.88 (5.60-44.70)	12.0 (5.60-44.70)	9.2 (1.59-14.52)
n	6	14	20	25
P^2-153	.0166	.040	.0210
P^2-155	.2482
% 7AAD^dim cells	15.61 ± 8.69	10.38 ± 8.12	11.70 ± 9.32	5.93 ± 4.37
Median (range)	14.28 (8.24-32.04)	7.70 (2.30-32.07)	8.70 (2.30-32.07)	3.94 (1.20-44.70)
n	6	17	23	24
P^2-153	.004	.047	.0136
P^2-155	.123
CD34⁺/Fas⁺cell fraction
% 7AAD^dimcells	40.29 ± 7.63	40.21 ± 23.24	39.21 ± 21.06	25.71 ± 17.73
Median (range)	38.89 (30.51-51.20)	37.57 (8.70-83.30)	37.56 (8.70-83.30)	23.86 (1.05-66.67)
n	6	14	20	24
P^2-153	.0406	.0468	.0310
P^2-155	.9015
CD34⁺/Fas⁻cell fraction
% 7AAD^dimcells	11.98 ± 10.64	6.21 ± 5.74	7.94 ± 7.73	6.78 ± 7.42
Median (range)	8.80 (2.60-32.51)	4.50 (1.50-24.08)	5.41 (1.50-32.51)	4.41 (0.92-32.00)
n	6	14	20	24
P^2-153	.0737	.7737	.2940
P^2-155	.1171

	Untreated RA patients^*	Treated RA patients^†	Total RA patients^*	Healthy controls
BMMC fraction
% CD34⁺cells	1.18 ± 0.44^‡	1.49 ± 1.06	1.42 ± 0.94	2.13 ± 1.02
Median (range)	1.30 (0.55-1.80)	1.20 (0.40-4.10)	1.20 (0.40-4.10)	1.90 (0.70-4.80)
n	6	20	26	37
P^2-153	.0142	.0091	.0016
P^2-155	.9519
% CD34⁺/CD38⁺ cells	0.92 ± 0.32	1.04 ± 0.76	1.03 ± 0.69	1.69 ± 0.89
Median (range)	1.00 (0.46-1.30)	1.84 (0.20-3.00)	0.92 (0.20-3.00)	1.60 (0.30-4.50)
n	6	20	26	37
P^2-153	.0439	.0038	.0017
P^2-155	.8550
% CD34⁺/CD38⁻ cells	0.26 ± 0.14	0.41 ± 0.34	0.36 ± 0.31	0.44 ± 0.28
Median (range)	0.25 (0.09-0.50)	0.30 (0.10-1.40)	0.25 (0.09-1.40)	0.38 (0.10-1.18)
n	6	20	26	37
P^2-153	.1188	.4871	.1890
P^2-155	.2726
CD34⁺cell fraction
% Fas⁺cells	15.78 ± 6.39	14.48 ± 10.33	15.02 ± 9.62	8.38 ± 3.68
Median (range)	14.48 (8.90-25.50)	9.88 (5.60-44.70)	12.0 (5.60-44.70)	9.2 (1.59-14.52)
n	6	14	20	25
P^2-153	.0166	.040	.0210
P^2-155	.2482
% 7AAD^dim cells	15.61 ± 8.69	10.38 ± 8.12	11.70 ± 9.32	5.93 ± 4.37
Median (range)	14.28 (8.24-32.04)	7.70 (2.30-32.07)	8.70 (2.30-32.07)	3.94 (1.20-44.70)
n	6	17	23	24
P^2-153	.004	.047	.0136
P^2-155	.123
CD34⁺/Fas⁺cell fraction
% 7AAD^dimcells	40.29 ± 7.63	40.21 ± 23.24	39.21 ± 21.06	25.71 ± 17.73
Median (range)	38.89 (30.51-51.20)	37.57 (8.70-83.30)	37.56 (8.70-83.30)	23.86 (1.05-66.67)
n	6	14	20	24
P^2-153	.0406	.0468	.0310
P^2-155	.9015
CD34⁺/Fas⁻cell fraction
% 7AAD^dimcells	11.98 ± 10.64	6.21 ± 5.74	7.94 ± 7.73	6.78 ± 7.42
Median (range)	8.80 (2.60-32.51)	4.50 (1.50-24.08)	5.41 (1.50-32.51)	4.41 (0.92-32.00)
n	6	14	20	24
P^2-153	.0737	.7737	.2940
P^2-155	.1171

Statistical analysis was performed using the nonparametric Mann-Whitney test. P value ≤ .05 was considered statistically significant.

Patients previously treated or not with methotrexate, corticosteroids, or other disease-modifying antirheumatic drugs.

†

Treated and untreated patients.

‡

Values are expressed as mean ± SD.

F2-153

Comparison between patient groups and healthy controls.

F2-155

Comparison between the groups of untreated and treated patients with RA.

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