Effect on tumor growth of L19–IL-2 fusion protein
| Tumor cell lines . | L19–IL-2 fusion protein . | IL–2/L19* . | Saline . | D1.3–IL-2 fusion protein . |
|---|---|---|---|---|
| C51† | 0.017 ± 0.008‡ | 0.228 ± 0.06 | 0.410 ± 0.07 | 0.251 ± 0.07 |
| N592† | 0.173 ± 0.07 | 0.705 ± 0.13 | 1.178 ± 0.3 | ND |
| N592† | 0.075 ± 0.02 | ND | 0.608 ± 0.08 | 0.385 ± 0.1 |
| F9† | 0.061 ± 0.062-153 | 0.665 ± 0.28 | 1.715 ± 0.23 | ND |
| F92-155 | 0.05 ± 0.012 | ND | 0.811 ± 0.24 | 0.597 ± 0.1 |
| F92-155 | 0.088 ± 0.04 | ND | 1.3 ± 0.36 | 0.9 ± 0.43 |
| Tumor cell lines . | L19–IL-2 fusion protein . | IL–2/L19* . | Saline . | D1.3–IL-2 fusion protein . |
|---|---|---|---|---|
| C51† | 0.017 ± 0.008‡ | 0.228 ± 0.06 | 0.410 ± 0.07 | 0.251 ± 0.07 |
| N592† | 0.173 ± 0.07 | 0.705 ± 0.13 | 1.178 ± 0.3 | ND |
| N592† | 0.075 ± 0.02 | ND | 0.608 ± 0.08 | 0.385 ± 0.1 |
| F9† | 0.061 ± 0.062-153 | 0.665 ± 0.28 | 1.715 ± 0.23 | ND |
| F92-155 | 0.05 ± 0.012 | ND | 0.811 ± 0.24 | 0.597 ± 0.1 |
| F92-155 | 0.088 ± 0.04 | ND | 1.3 ± 0.36 | 0.9 ± 0.43 |
Values reported represent the mean tumor weight (g) ± SE; groups of 6 mice were used for each experiment.
ND indicates not determined.
Equimolar mixture of scFv L19 and recombinant IL-2.
Tumoral cells grown in athymic nude mice.
A tumoral mass grew in only 4 of 6 mice.
A tumoral mass grew in only 3 of 6 mice.
Tumoral cells grown in syngeneic 129 strain mice.