Characteristics and responses of patients revaccinated with Id-KLH protein + SAF1
| Patient . | Interval from DC to Id-KLH vaccination . | Sites of disease . | Anti-Id response . | Clinical response, time to progression . | |
|---|---|---|---|---|---|
| T cell . | Ab . | ||||
| D2 | 18 mos | Cervical, iliac, peri-aortic | + | − | PR, 14 mos |
| D5 | 16 mos | Skin, cervical, axillary, inguinal | − | − | PD |
| D6 | 16 mos | Parotid, axillary, mesenteric, peri-aortic | − | − | PD |
| D8 | 8 mos | Axillary, peri-aortic | − | +μ3-150 | CR, 48+ mos |
| D10 | 22 mos | Skin, peri-aortic, axillary, inguinal | − | − | PD |
| D123-151 | 33 mos | Cervical, axillary, iliac, inguinal, BM | + | − | CRu, 16 mos |
| 49 mos3-152 | Cervical, BM | + | − | CR, 1+ mos | |
| Patient . | Interval from DC to Id-KLH vaccination . | Sites of disease . | Anti-Id response . | Clinical response, time to progression . | |
|---|---|---|---|---|---|
| T cell . | Ab . | ||||
| D2 | 18 mos | Cervical, iliac, peri-aortic | + | − | PR, 14 mos |
| D5 | 16 mos | Skin, cervical, axillary, inguinal | − | − | PD |
| D6 | 16 mos | Parotid, axillary, mesenteric, peri-aortic | − | − | PD |
| D8 | 8 mos | Axillary, peri-aortic | − | +μ3-150 | CR, 48+ mos |
| D10 | 22 mos | Skin, peri-aortic, axillary, inguinal | − | − | PD |
| D123-151 | 33 mos | Cervical, axillary, iliac, inguinal, BM | + | − | CRu, 16 mos |
| 49 mos3-152 | Cervical, BM | + | − | CR, 1+ mos | |
CR indicates complete response; CRu, complete response unconfirmed (normalization of radiographs, equivocal findings in bone marrow); PR, partial response; PD, progressive disease; BM, bone marrow.
IgM, but not IgG anti-Id antibodies detectable in serum.
Adjuvant = ISAF (“incomplete” SAF1, without threonyl MDP component).
Repeat course of Id-KLH protein + ISAF vaccinations (vaccine course 3).