Table 5.

The 70 most significantly up-regulated genes in MM in comparison with normal bone marrow PCs

Accession5-150FunctionGene symbol5-151χ2WRS5-152P
U09579 Cell cycle CDKN1A 53.33 3.65  × 10−11 
U78525 Amino acid synthesis EIF3S9 49.99 2.25  × 10−12 
HT5158 DNA synthesis GMPS 47.11 4.30  × 10−12 
X57129 Histone H1F2 46.59 5.78  × 10−13 
M55210 Adhesion LAMC1 45.63 1.34  × 10−9 
L77886 Signaling, phosphatase PTPRK 45.62 5.42  × 10−10 
U73167 Glycosaminoglycan catabolism HYAL3 44.78 1.07  × 10−10 
X16416 Oncogene, kinase ABL1 43.10 3.96  × 10−14 
U57316 Transcription GCN5L2 43.04 1.36  × 10−12 
Y09022 Protein glycosylation NOT56L5-151 42.05 5.53  × 10−10 
M25077 RNA binding SSA2 41.26 1.69  × 10−7 
AC002115 Mitochondrial respiration COX6B 41.16 2.16  × 10−8 
Y07707 Transcription NRF5-151 37.59 4.79  × 10−10 
L22005 Protein ubiquination CDC34 34.50 2.89  × 10−6 
X66899 Transcription EWSR1 34.39 4.23  × 10−8 
D50912 RNA binding RBM10 33.93 2.61  × 10−6 
HT4824 Amino acid synthesis CBS 33.77 1.49  × 10−6 
U10324 Transcription ILF3 33.33 3.66  × 10−11 
AD000684 Oncogene, transcription USF2 32.18 7.41  × 10−11 
U68723 Cell cycle CHES1 31.68 1.03  × 10−6 
X16323 Signaling, growth factor HGF 30.67 4.82  × 10−9 
U24183 Metabolism PFKM 30.47 8.92  × 10−10 
D13645 Unknown KIAA00205-151 30.47 7.40  × 10−6 
S85655 Signaling, growth arrest PHB 29.37 1.32  × 10−8 
X73478 Signaling, phosphatase PPP2R4 28.32 6.92  × 10−9 
L77701 Mitochondrial respiration COX17 27.81 1.33  × 10−6 
U20657 Oncogene, proteasome USP4 27.71 2.31  × 10−6 
M59916 Signaling, DAG signaling SMPD1 27.49 3.52  × 10−8 
D16688 Oncogene, DNA binding MLLT3 27.24 6.97  × 10−13 
X90392 DNA endonuclease DNASE1L1 26.98 4.72  × 10−7 
U07424 Amino acid synthesis FARSL 26.93 1.66  × 10−6 
X54199 DNA synthesis GART 26.57 9.61  × 10−11 
L06175 Unknown P5-15-151 26.57 5.16  × 10−7 
M55267 Unknown EVI2A 25.92 3.79  × 10−6 
M87507 Protein degradation CASP1 25.78 5.46  × 10−7 
M90356 Transcription BTF3L2 25.78 9.68  × 10−8 
U35637 Cytoskeletal matrix NEB 25.40 9.15  × 10−6 
L06845 Amino acid synthesis CARS 25.34 5.39  × 10−8 
U81001 DNA, nuclear matrix attachment SNURF 24.58 4.54  × 10−5 
U76189 Heparan sulfate synthesis EXTL2 24.58 7.28  × 10−6 
U53225 Protein trafficking SNX1 24.48 5.53  × 10−7 
X04366 Protein degradation CAPN1 24.35 1.26  × 10−9 
U77456 Protein folding NAP1L4 24.27 4.23  × 10−10 
L42379 Signaling, growth arrest QSCN6 24.27 1.28  × 10−10 
U09578 Signaling, kinase MAPKAPK3 24.27 2.35  × 10−9 
Z80780 Histone H2BFH 24.27 3.44  × 10−12 
HT4899 Oncogene, transcription MYC 24.27 1.77  × 10−5 
M74088 Signaling, b-catenin regulator APC 23.94 1.50  × 10−5 
X57985 Histone H2BFQ 23.90 3.25  × 10−12 
X79882 Drug resistance MVP 23.47 1.77  × 10−11 
X77383 Protein degradation CTSO 23.18 4.68  × 10−7 
M91592 Transcription ZNF76 23.16 1.12  × 10−8 
X63692 DNA methyltransferase DNMT1 23.12 5.15  × 10−11 
M60752 Histone H2AFO 21.60 1.46  × 10−8 
M96684 Transcription PURA 21.25 4.54  × 10−5 
U16660 Metabolism ECH1 21.18 5.52  × 10−5 
M86737 DNA repair SSRP1 20.60 2.62  × 10−5 
U35113 Histone deacetylase MTA1 20.60 6.67  × 10−10 
X81788 Unknown ICT1 20.42 2.97  × 10−7 
HT2217 Signaling MUC2A 20.33 2.61  × 10−7 
M62324 Unknown MRF-15-151 20.31 3.98  × 10−9 
U09367 Transcription ZNF136 20.30 7.72  × 10−9 
X89985 Cytoskeletal matrix BCL7B 19.81 5.50  × 10−9 
L19871 Transcription repression ATF3 19.43 1.13  × 10−6 
X69398 Adhesion CD47 19.16 6.44  × 10−7 
X05323 Signaling, macrophage inhibitor MOX2 19.16 8.58  ×  10−6 
X04741 Protein ubiquination UCHL1 19.14 9.76  ×  10−5 
D87683 Vesicular transport TSC1 19.12 6.81  ×  10−6 
D17525 Complement cascade MASP1 18.81 4.05  ×  10−7 
Accession5-150FunctionGene symbol5-151χ2WRS5-152P
U09579 Cell cycle CDKN1A 53.33 3.65  × 10−11 
U78525 Amino acid synthesis EIF3S9 49.99 2.25  × 10−12 
HT5158 DNA synthesis GMPS 47.11 4.30  × 10−12 
X57129 Histone H1F2 46.59 5.78  × 10−13 
M55210 Adhesion LAMC1 45.63 1.34  × 10−9 
L77886 Signaling, phosphatase PTPRK 45.62 5.42  × 10−10 
U73167 Glycosaminoglycan catabolism HYAL3 44.78 1.07  × 10−10 
X16416 Oncogene, kinase ABL1 43.10 3.96  × 10−14 
U57316 Transcription GCN5L2 43.04 1.36  × 10−12 
Y09022 Protein glycosylation NOT56L5-151 42.05 5.53  × 10−10 
M25077 RNA binding SSA2 41.26 1.69  × 10−7 
AC002115 Mitochondrial respiration COX6B 41.16 2.16  × 10−8 
Y07707 Transcription NRF5-151 37.59 4.79  × 10−10 
L22005 Protein ubiquination CDC34 34.50 2.89  × 10−6 
X66899 Transcription EWSR1 34.39 4.23  × 10−8 
D50912 RNA binding RBM10 33.93 2.61  × 10−6 
HT4824 Amino acid synthesis CBS 33.77 1.49  × 10−6 
U10324 Transcription ILF3 33.33 3.66  × 10−11 
AD000684 Oncogene, transcription USF2 32.18 7.41  × 10−11 
U68723 Cell cycle CHES1 31.68 1.03  × 10−6 
X16323 Signaling, growth factor HGF 30.67 4.82  × 10−9 
U24183 Metabolism PFKM 30.47 8.92  × 10−10 
D13645 Unknown KIAA00205-151 30.47 7.40  × 10−6 
S85655 Signaling, growth arrest PHB 29.37 1.32  × 10−8 
X73478 Signaling, phosphatase PPP2R4 28.32 6.92  × 10−9 
L77701 Mitochondrial respiration COX17 27.81 1.33  × 10−6 
U20657 Oncogene, proteasome USP4 27.71 2.31  × 10−6 
M59916 Signaling, DAG signaling SMPD1 27.49 3.52  × 10−8 
D16688 Oncogene, DNA binding MLLT3 27.24 6.97  × 10−13 
X90392 DNA endonuclease DNASE1L1 26.98 4.72  × 10−7 
U07424 Amino acid synthesis FARSL 26.93 1.66  × 10−6 
X54199 DNA synthesis GART 26.57 9.61  × 10−11 
L06175 Unknown P5-15-151 26.57 5.16  × 10−7 
M55267 Unknown EVI2A 25.92 3.79  × 10−6 
M87507 Protein degradation CASP1 25.78 5.46  × 10−7 
M90356 Transcription BTF3L2 25.78 9.68  × 10−8 
U35637 Cytoskeletal matrix NEB 25.40 9.15  × 10−6 
L06845 Amino acid synthesis CARS 25.34 5.39  × 10−8 
U81001 DNA, nuclear matrix attachment SNURF 24.58 4.54  × 10−5 
U76189 Heparan sulfate synthesis EXTL2 24.58 7.28  × 10−6 
U53225 Protein trafficking SNX1 24.48 5.53  × 10−7 
X04366 Protein degradation CAPN1 24.35 1.26  × 10−9 
U77456 Protein folding NAP1L4 24.27 4.23  × 10−10 
L42379 Signaling, growth arrest QSCN6 24.27 1.28  × 10−10 
U09578 Signaling, kinase MAPKAPK3 24.27 2.35  × 10−9 
Z80780 Histone H2BFH 24.27 3.44  × 10−12 
HT4899 Oncogene, transcription MYC 24.27 1.77  × 10−5 
M74088 Signaling, b-catenin regulator APC 23.94 1.50  × 10−5 
X57985 Histone H2BFQ 23.90 3.25  × 10−12 
X79882 Drug resistance MVP 23.47 1.77  × 10−11 
X77383 Protein degradation CTSO 23.18 4.68  × 10−7 
M91592 Transcription ZNF76 23.16 1.12  × 10−8 
X63692 DNA methyltransferase DNMT1 23.12 5.15  × 10−11 
M60752 Histone H2AFO 21.60 1.46  × 10−8 
M96684 Transcription PURA 21.25 4.54  × 10−5 
U16660 Metabolism ECH1 21.18 5.52  × 10−5 
M86737 DNA repair SSRP1 20.60 2.62  × 10−5 
U35113 Histone deacetylase MTA1 20.60 6.67  × 10−10 
X81788 Unknown ICT1 20.42 2.97  × 10−7 
HT2217 Signaling MUC2A 20.33 2.61  × 10−7 
M62324 Unknown MRF-15-151 20.31 3.98  × 10−9 
U09367 Transcription ZNF136 20.30 7.72  × 10−9 
X89985 Cytoskeletal matrix BCL7B 19.81 5.50  × 10−9 
L19871 Transcription repression ATF3 19.43 1.13  × 10−6 
X69398 Adhesion CD47 19.16 6.44  × 10−7 
X05323 Signaling, macrophage inhibitor MOX2 19.16 8.58  ×  10−6 
X04741 Protein ubiquination UCHL1 19.14 9.76  ×  10−5 
D87683 Vesicular transport TSC1 19.12 6.81  ×  10−6 
D17525 Complement cascade MASP1 18.81 4.05  ×  10−7 
F5-150

Accession numbers listed are GenBank numbers, except those beginning with “HT,” which are provided by the Institute of Genomic Research (TIGR).

F5-151

Gene symbol not HUGO approved.

F5-152

Wilcoxon rank sum test.

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