Table 4.

The 50 most significantly down-regulated genes in MM in comparison with normal bone marrow PCs

Accession4-150FunctionGene symbol4-151χ2WRS‡P value
L36033 CXC chemokine SDF1 48.45 3.05 × 10−12 
M63928 Signaling TNFRSF7 48.45 6.35 × 10−11 
U64998 Ribonuclease RNASE6 46.44 2.82 × 10−9 
M20902 Lipoprotein signaling APOC1 45.62 4.63 × 10−10 
M26602 Immunity DEFA1 40.75 1.06 × 10−12 
M21119 Immunity LYZ 40.73 6.24 × 10−10 
M14636 Metabolism PYGL 39.84 1.15 × 10−10 
M26311 Calcium signaling S100A9 38.96 3.60 × 10−13 
M54992 Signaling CD72 36.14 2.40 × 10−9 
X16832 Protein degradation CTSH 35.26 1.81 × 10−12 
M12529 Lipoprotein signaling APOE 34.50 3.95 × 10−14 
M15395 Adhesion ITGB2 34.02 1.74 × 10−13 
Z74616 Extracellular matrix COL1A2 34.02 8.06 × 10−11 
HT2152 Receptor signaling CD163 33.01 1.66 × 10−12 
U97105 Pyrimidine metabolism DPYSL2 32.52 2.22 × 10−10 
U81787 Signaling WNT10B 32.50 1.77 × 10−5 
HT3165 Receptor tyrosine kinase AXL 31.36 5.26 × 10−11 
M83667 Transcription CEBPD 31.19 4.69 × 10−10 
L33930 Receptor signaling CD24 30.33 1.56 × 10−14 
D83657 Calcium signaling S100A12 29.91 6.58 × 10−8 
M11313 Proteinase inhibitor A2M 29.91 1.07 × 10−10 
M31158 Signaling PRKAR2B 29.91 2.20 × 10−9 
U24577 Lipoprotein signaling PLA2G7 29.78 2.08 × 10−10 
M16279 Adhesion MIC2 28.75 8.01 × 10−11 
HT2811 Cell cycle CDK8 28.32 6.53 × 10−9 
M26167 CXC chemokine PF4V1 27.35 4.68 × 10−11 
U44111 Metabolism HNMT 27.24 2.07 × 10−11 
X59871 Transcription TCF7 26.79 7.16 × 10−10 
X67235 Transcription HHEX 25.21 2.07 × 10−10 
U19713 Calcium signaling AIF1 25.21 2.57 × 10−10 
Y08136 Apoptosis ASM3A4-151 24.74 3.30 × 10−8 
M97676 Transcription MSX1 24.58 9.80 × 10−5 
M64590 Housekeeping GLDC 24.27 4.10 × 10−8 
M20203 Protease ELA2 24.03 6.36 × 10−12 
M30257 Adhesion VCAM1 23.42 1.71 × 10−10 
M93221 Mediates endocytosis MRC1 23.30 1.15 × 10−7 
S75256 Lipoprotein signaling LCN2 23.30 4.17 × 10−7 
U97188 RNA binding KOC14-151 22.47 5.86 × 10−9 
Z23091 Adhesion GP5 22.47 7.58 × 10−7 
M34344 Adhesion ITGA2B 21.99 8.00 × 10−8 
M25897 CXC chemokine PF4 21.89 1.12 × 10−8 
M31994 Housekeeping ALDH1A1 21.36 4.86 × 10−9 
Z31690 Lipoprotein signaling LIPA 20.67 1.50 × 10−9 
S80267 Signaling SYK 20.42 5.90 × 10−5 
U00921 Signaling LY117 18.83 1.57 × 10−8 
Accession4-150FunctionGene symbol4-151χ2WRS‡P value
L36033 CXC chemokine SDF1 48.45 3.05 × 10−12 
M63928 Signaling TNFRSF7 48.45 6.35 × 10−11 
U64998 Ribonuclease RNASE6 46.44 2.82 × 10−9 
M20902 Lipoprotein signaling APOC1 45.62 4.63 × 10−10 
M26602 Immunity DEFA1 40.75 1.06 × 10−12 
M21119 Immunity LYZ 40.73 6.24 × 10−10 
M14636 Metabolism PYGL 39.84 1.15 × 10−10 
M26311 Calcium signaling S100A9 38.96 3.60 × 10−13 
M54992 Signaling CD72 36.14 2.40 × 10−9 
X16832 Protein degradation CTSH 35.26 1.81 × 10−12 
M12529 Lipoprotein signaling APOE 34.50 3.95 × 10−14 
M15395 Adhesion ITGB2 34.02 1.74 × 10−13 
Z74616 Extracellular matrix COL1A2 34.02 8.06 × 10−11 
HT2152 Receptor signaling CD163 33.01 1.66 × 10−12 
U97105 Pyrimidine metabolism DPYSL2 32.52 2.22 × 10−10 
U81787 Signaling WNT10B 32.50 1.77 × 10−5 
HT3165 Receptor tyrosine kinase AXL 31.36 5.26 × 10−11 
M83667 Transcription CEBPD 31.19 4.69 × 10−10 
L33930 Receptor signaling CD24 30.33 1.56 × 10−14 
D83657 Calcium signaling S100A12 29.91 6.58 × 10−8 
M11313 Proteinase inhibitor A2M 29.91 1.07 × 10−10 
M31158 Signaling PRKAR2B 29.91 2.20 × 10−9 
U24577 Lipoprotein signaling PLA2G7 29.78 2.08 × 10−10 
M16279 Adhesion MIC2 28.75 8.01 × 10−11 
HT2811 Cell cycle CDK8 28.32 6.53 × 10−9 
M26167 CXC chemokine PF4V1 27.35 4.68 × 10−11 
U44111 Metabolism HNMT 27.24 2.07 × 10−11 
X59871 Transcription TCF7 26.79 7.16 × 10−10 
X67235 Transcription HHEX 25.21 2.07 × 10−10 
U19713 Calcium signaling AIF1 25.21 2.57 × 10−10 
Y08136 Apoptosis ASM3A4-151 24.74 3.30 × 10−8 
M97676 Transcription MSX1 24.58 9.80 × 10−5 
M64590 Housekeeping GLDC 24.27 4.10 × 10−8 
M20203 Protease ELA2 24.03 6.36 × 10−12 
M30257 Adhesion VCAM1 23.42 1.71 × 10−10 
M93221 Mediates endocytosis MRC1 23.30 1.15 × 10−7 
S75256 Lipoprotein signaling LCN2 23.30 4.17 × 10−7 
U97188 RNA binding KOC14-151 22.47 5.86 × 10−9 
Z23091 Adhesion GP5 22.47 7.58 × 10−7 
M34344 Adhesion ITGA2B 21.99 8.00 × 10−8 
M25897 CXC chemokine PF4 21.89 1.12 × 10−8 
M31994 Housekeeping ALDH1A1 21.36 4.86 × 10−9 
Z31690 Lipoprotein signaling LIPA 20.67 1.50 × 10−9 
S80267 Signaling SYK 20.42 5.90 × 10−5 
U00921 Signaling LY117 18.83 1.57 × 10−8 
F4-150

Accession numbers listed are GenBank numbers, except those beginning with “HT,” which are provided by the Institute of Genomic Research (TIGR).

F4-151

Gene symbol not HUGO approved.

‡

Wilcoxon rank sum test.

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