Activity and antigen of factor VII variants in patient's plasma or in conditioned medium
| . | Wt . | 331Ser . | 283Ser . | 331Ala . | 283Ala . |
|---|---|---|---|---|---|
| Activity, %* | |||||
| Plasma, FVIIc | 100 | 0.6-1.9‡ | 2.5 | NA | NA |
| Plasma† | 100 | 0.7 ± 0.2 | ND | NA | NA |
| rFVII† | 100 | 2.7 ± 1.1 | ND | 18.1 ± 1.1 | 7.2 ± 2.2 |
| Antigen | |||||
| Plasma, % | 100 | 85-100‡ | 100 | NA | NA |
| rFVII, ng/mL | 119 ± 70 | 105 ± 71 | 101 ± 80 | 145 ± 84 | 85 ± 58 |
| . | Wt . | 331Ser . | 283Ser . | 331Ala . | 283Ala . |
|---|---|---|---|---|---|
| Activity, %* | |||||
| Plasma, FVIIc | 100 | 0.6-1.9‡ | 2.5 | NA | NA |
| Plasma† | 100 | 0.7 ± 0.2 | ND | NA | NA |
| rFVII† | 100 | 2.7 ± 1.1 | ND | 18.1 ± 1.1 | 7.2 ± 2.2 |
| Antigen | |||||
| Plasma, % | 100 | 85-100‡ | 100 | NA | NA |
| rFVII, ng/mL | 119 ± 70 | 105 ± 71 | 101 ± 80 | 145 ± 84 | 85 ± 58 |
Results obtained in 5 independent sets of experiments are reported as mean ± SD.
Wt indicates wild type; FVIIc, factor VIIc; rFVII, recombinant FVII; ND, not detectable, and NA, not applicable.
Percentage of pooled normal plasma (PNP) or of rWtFVII.
Factor Xa generation activity.
Range of FVII levels in plasma of 5 homozygous patients.