PML-RARα mutation analyses in multiple-relapse APL cases
| Case no. . | PML-RARα type . | Base substitution* . | Missense mutation* . |
|---|---|---|---|
| 1 | L | C1322T | Pro407Ser |
| 2 | S | — | — |
| 3 | L | — | — |
| 4 | S | C982T | Arg294Trp |
| 5 | L | — | — |
| 6 | L | G967A | Gly289Arg |
| 7 | V | A723T | Lys207Asn |
| 8 | L | G917A | Arg272Gln |
| Case no. . | PML-RARα type . | Base substitution* . | Missense mutation* . |
|---|---|---|---|
| 1 | L | C1322T | Pro407Ser |
| 2 | S | — | — |
| 3 | L | — | — |
| 4 | S | C982T | Arg294Trp |
| 5 | L | — | — |
| 6 | L | G967A | Gly289Arg |
| 7 | V | A723T | Lys207Asn |
| 8 | L | G917A | Arg272Gln |
AML indicates acute promyelocytic leukemia.
Nucleotide and amino acid numbers correspond to that for normal RARα1.44