Table 5.

Relationship between kinetics of the molecular response and disease recurrence

PCR negativization in the bone marrow following rituximabEvent rate (%)χ2Log rank
Rapid and sustained
(at wk +12, +28, and +44) 
4/33 (12) — —  
Late but sustained
(at wk +28 and +44) 
2/12 (17) 0.69 0.84 
Transient
(at wk +12 and +28 but not +44) 
8/17 (47) 0.006 0.003 
Absent 7/14 (50) 0.005 0.01 
PCR negativization in the bone marrow following rituximabEvent rate (%)χ2Log rank
Rapid and sustained
(at wk +12, +28, and +44) 
4/33 (12) — —  
Late but sustained
(at wk +28 and +44) 
2/12 (17) 0.69 0.84 
Transient
(at wk +12 and +28 but not +44) 
8/17 (47) 0.006 0.003 
Absent 7/14 (50) 0.005 0.01 
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