ADA activity in lymphoid cells of Sib A and Sib B, family 1
| . | Sib A . | Sib B . | Normal3-150 . |
|---|---|---|---|
| Pretreatment | |||
| T cells | 99 | 1576 | |
| After 7 mo of treatment with PEG-ADA | |||
| PBL | 100 | 229 | 1197 ± 516 |
| T cells | 119 | 173 | 2047 ± 1360 |
| HTLV-T LCL | 31 | 98 | 2280 |
| EBV-B LCL | 63 | 5423 | 7435 ± 3285 |
| . | Sib A . | Sib B . | Normal3-150 . |
|---|---|---|---|
| Pretreatment | |||
| T cells | 99 | 1576 | |
| After 7 mo of treatment with PEG-ADA | |||
| PBL | 100 | 229 | 1197 ± 516 |
| T cells | 119 | 173 | 2047 ± 1360 |
| HTLV-T LCL | 31 | 98 | 2280 |
| EBV-B LCL | 63 | 5423 | 7435 ± 3285 |
Values shown (nmol/h/mg extract protein) have been corrected by subtracting activity resistant to the specific ADA inhibitor deoxycoformycin (90%-99% of ADA activity in patient cells was inhibited).
ADA activities (mean ± SD) for normal (control) PBL, IL-2-dependent T cells, and EBV-B LCLs are published values for this laboratory.20 57 The control for the HTLV-T LCL is for a single cell line (mean of two determinations).