Results of multivariable analysis
| Parameter . | TRM . | Relapse . | DFS . | Survival . | ||||
|---|---|---|---|---|---|---|---|---|
| RR . | P . | RR . | P . | RR . | P . | RR . | P . | |
| Type of transplant | ||||||||
| Haploidentical | 1 | .008* | 1 | .014 | 1 | .006 | 1 | .003 |
| Matched unrelated | 0.35 (0.19-0.66) | .001 | 0.45 (0.24-0.83) | .01 | 0.50 (0.32-0.79) | .003 | 0.48 (0.30-0.76) | .002 |
| Mismatched unrelated | 0.76 (0.42-1.35) | .35 | 0.43 (0.21-0.84) | .014 | 0.84 (0.51-1.37) | .48 | 0.87 (0.54-1.48) | .67 |
| Matched vs mismatched† | 0.47 (0.26-0.84) | .01 | 1.04 (0.54-2.01) | .90 | 0.60 (0.38-.95) | .029 | 0.54 (0.33-0.86) | .01 |
| Recipient age, y | ||||||||
| Younger than 20 | 1 | .0002 | NS | NS | NS | |||
| 20 or older | 1.03 (1.01-1.04) | |||||||
| Growth factor | ||||||||
| No | NS | NS | 1 | .018 | 1 | .014 | ||
| Yes | 1.67 (1.09-2.56) | 1.72 (1.11-2.63) | ||||||
| Risk group | ||||||||
| Low | NS | 1 | < .0001 | 1 | < .0001 | 1 | < .0001 | |
| High | 3.74 (2.11-6.65) | 2.30 (1.59-3.35) | 2.38 (1.61-3.51) | |||||
| Parameter . | TRM . | Relapse . | DFS . | Survival . | ||||
|---|---|---|---|---|---|---|---|---|
| RR . | P . | RR . | P . | RR . | P . | RR . | P . | |
| Type of transplant | ||||||||
| Haploidentical | 1 | .008* | 1 | .014 | 1 | .006 | 1 | .003 |
| Matched unrelated | 0.35 (0.19-0.66) | .001 | 0.45 (0.24-0.83) | .01 | 0.50 (0.32-0.79) | .003 | 0.48 (0.30-0.76) | .002 |
| Mismatched unrelated | 0.76 (0.42-1.35) | .35 | 0.43 (0.21-0.84) | .014 | 0.84 (0.51-1.37) | .48 | 0.87 (0.54-1.48) | .67 |
| Matched vs mismatched† | 0.47 (0.26-0.84) | .01 | 1.04 (0.54-2.01) | .90 | 0.60 (0.38-.95) | .029 | 0.54 (0.33-0.86) | .01 |
| Recipient age, y | ||||||||
| Younger than 20 | 1 | .0002 | NS | NS | NS | |||
| 20 or older | 1.03 (1.01-1.04) | |||||||
| Growth factor | ||||||||
| No | NS | NS | 1 | .018 | 1 | .014 | ||
| Yes | 1.67 (1.09-2.56) | 1.72 (1.11-2.63) | ||||||
| Risk group | ||||||||
| Low | NS | 1 | < .0001 | 1 | < .0001 | 1 | < .0001 | |
| High | 3.74 (2.11-6.65) | 2.30 (1.59-3.35) | 2.38 (1.61-3.51) | |||||
Haploidentical, recipient age < 20, no growth factor use, and low-risk disease were all assigned a relative risk of 1 and served as the reference groups.
Results of 95% confidence intervals are shown in parentheses.
Donor age, gender, gender match, disease type, type of antibody used for T-cell depletion, CD34 cell dose, and donor/recipient CMV status were additional variables that were analyzed but were not significant for any outcomes. CD34 cell dose was analyzed as a categorical variable using the following groupings: < 2 × 106, 2-5 × 106, > 5 × 106, and unknown.
NS indicates not significant. For other abbreviations, see Table 1.
Two degree of freedom test was of no difference in donor type.
Comparison of transplantation outcomes among recipients of matched unrelated and one-antigen–mismatched unrelated marrow grafts.