Transmission-disequilibrium test results for linkage between familial Hodgkin disease and noncandidate alleles at HLA class II and transporter associated with antigen processing loci, National Cancer Institute, Bethesda, MD, 1978-1993
| . | All familial HD (n = 28) . | Familial NSHD only (n = 23) . | Unaffected siblings (n = 40)2-154 . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T . | NT . | χ2 . | P† . | T . | NT . | χ2 . | P† . | T . | NT . | χ2 . | P† . | |
| DRB1 | ||||||||||||
| *0301 | 1 | 6 | 3.57 | .24 | — | — | — | — | 7 | 9 | 0.25 | — |
| *0401 | 5 | 4 | 0.11 | — | 3 | 4 | 0.14 | > .99 | 11 | 5 | 2.25 | .53 |
| *1300 | 3 | 6 | 1.00 | — | 3 | 4 | 0.14 | > .99 | 5 | 3 | 0.50 | — |
| All others‡ | 36 | 29 | — | — | 32 | 30 | — | — | 13 | 14 | — | — |
| Total | 45 | 45 | 4.07 | .25 | 38 | 38 | 0.23 | .97 | 64 | 64 | 2.27 | .52 |
| DQA1 | ||||||||||||
| *0101 | 5 | 7 | 0.33 | — | 1 | 7 | 4.50 | — | 7 | 8 | 0.07 | — |
| *0102 | 19 | 9 | 3.57 | .29 | 19 | 5 | 8.17 | .02 | 18 | 20 | 0.11 | — |
| *0301 | 5 | 5 | 0.00 | — | 3 | 5 | 0.50 | — | 8 | 6 | 0.29 | > .99 |
| *0501 | 11 | 12 | 0.04 | — | 10 | 9 | 0.05 | — | 14 | 13 | 0.04 | — |
| All others‡ | 3 | 10 | — | — | 3 | 10 | — | — | 9 | 9 | — | — |
| Total | 43 | 43 | 6.17 | .19 | 36 | 36 | 13.59 | .01 | 56 | 56 | 0.41 | .98 |
| DQB1 | ||||||||||||
| *201 | 3 | 11 | 4.57 | .13 | 3 | 8 | 2.27 | .53 | 9 | 13 | 0.73 | — |
| *0301 | 10 | 6 | 1.00 | — | 7 | 6 | 0.08 | — | 11 | 6 | 1.47 | .90 |
| *0302 | 2 | 5 | 1.29 | — | 2 | 5 | 1.29 | — | 7 | 4 | 0.82 | — |
| All others‡ | 25 | 18 | — | — | 21 | 14 | — | — | 26 | 30 | — | — |
| Total | 40 | 40 | 6.00 | .11 | 33 | 33 | 3.78 | .29 | 53 | 53 | 2.48 | .48 |
| DRB1-DQA1-DQB1 | ||||||||||||
| *0301-*0501-*0201 | 1 | 6 | 3.57 | .18 | — | — | — | — | 7 | 9 | 0.25 | — |
| *0701-*0201-*0201 | 2 | 5 | 1.29 | — | 2 | 5 | 1.29 | .77 | 4 | 6 | 0.40 | > .99 |
| All others‡ | 42 | 34 | — | — | 36 | 33 | — | — | 46 | 42 | — | — |
| Total | 45 | 45 | 3.80 | .15 | 38 | 38 | 0.71 | .70 | 57 | 57 | 0.55 | .76 |
| DRB3-5 | ||||||||||||
| DRB3*0101 | 2 | 6 | 2.00 | — | — | — | — | — | 4 | 10 | 2.57 | .54 |
| DRB3*0202 | 7 | 5 | 0.33 | — | 5 | 5 | 0.00 | — | 8 | 5 | 0.69 | — |
| DRB4*0101 | 7 | 13 | 1.80 | — | 5 | 13 | 3.56 | — | 16 | 13 | 0.31 | — |
| DRB5*0101 | 16 | 6 | 4.55 | .16 | 16 | 5 | 5.76 | .08 | 12 | 15 | 0.33 | — |
| All others‡ | 5 | 7 | — | — | 5 | 8 | — | — | 11 | 8 | — | — |
| Total | 37 | 37 | 7.20 | .13 | 31 | 31 | 7.51 | .11 | 51 | 51 | 3.50 | .48 |
| TAP1 Ile333Val | ||||||||||||
| Ile | 14 | 6 | 3.20 | .07 | 12 | 3 | 5.40 | .02 | 15 | 13 | 0.14 | .71 |
| TAP1 Asp637Gly | ||||||||||||
| Asp | 7 | 6 | 0.08 | .78 | 5 | 4 | 0.11 | .74 | 14 | 7 | 2.33 | .13 |
| TAP2 Ile379Val | ||||||||||||
| Ile | 5 | 5 | 0.00 | > .99 | 3 | 5 | 0.50 | .48 | 9 | 3 | 3.00 | .08 |
| TAP2 Ala665Thr | ||||||||||||
| Ala | 5 | 4 | 0.11 | .74 | 3 | 4 | 0.14 | .71 | 5 | 7 | 0.33 | .57 |
| . | All familial HD (n = 28) . | Familial NSHD only (n = 23) . | Unaffected siblings (n = 40)2-154 . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T . | NT . | χ2 . | P† . | T . | NT . | χ2 . | P† . | T . | NT . | χ2 . | P† . | |
| DRB1 | ||||||||||||
| *0301 | 1 | 6 | 3.57 | .24 | — | — | — | — | 7 | 9 | 0.25 | — |
| *0401 | 5 | 4 | 0.11 | — | 3 | 4 | 0.14 | > .99 | 11 | 5 | 2.25 | .53 |
| *1300 | 3 | 6 | 1.00 | — | 3 | 4 | 0.14 | > .99 | 5 | 3 | 0.50 | — |
| All others‡ | 36 | 29 | — | — | 32 | 30 | — | — | 13 | 14 | — | — |
| Total | 45 | 45 | 4.07 | .25 | 38 | 38 | 0.23 | .97 | 64 | 64 | 2.27 | .52 |
| DQA1 | ||||||||||||
| *0101 | 5 | 7 | 0.33 | — | 1 | 7 | 4.50 | — | 7 | 8 | 0.07 | — |
| *0102 | 19 | 9 | 3.57 | .29 | 19 | 5 | 8.17 | .02 | 18 | 20 | 0.11 | — |
| *0301 | 5 | 5 | 0.00 | — | 3 | 5 | 0.50 | — | 8 | 6 | 0.29 | > .99 |
| *0501 | 11 | 12 | 0.04 | — | 10 | 9 | 0.05 | — | 14 | 13 | 0.04 | — |
| All others‡ | 3 | 10 | — | — | 3 | 10 | — | — | 9 | 9 | — | — |
| Total | 43 | 43 | 6.17 | .19 | 36 | 36 | 13.59 | .01 | 56 | 56 | 0.41 | .98 |
| DQB1 | ||||||||||||
| *201 | 3 | 11 | 4.57 | .13 | 3 | 8 | 2.27 | .53 | 9 | 13 | 0.73 | — |
| *0301 | 10 | 6 | 1.00 | — | 7 | 6 | 0.08 | — | 11 | 6 | 1.47 | .90 |
| *0302 | 2 | 5 | 1.29 | — | 2 | 5 | 1.29 | — | 7 | 4 | 0.82 | — |
| All others‡ | 25 | 18 | — | — | 21 | 14 | — | — | 26 | 30 | — | — |
| Total | 40 | 40 | 6.00 | .11 | 33 | 33 | 3.78 | .29 | 53 | 53 | 2.48 | .48 |
| DRB1-DQA1-DQB1 | ||||||||||||
| *0301-*0501-*0201 | 1 | 6 | 3.57 | .18 | — | — | — | — | 7 | 9 | 0.25 | — |
| *0701-*0201-*0201 | 2 | 5 | 1.29 | — | 2 | 5 | 1.29 | .77 | 4 | 6 | 0.40 | > .99 |
| All others‡ | 42 | 34 | — | — | 36 | 33 | — | — | 46 | 42 | — | — |
| Total | 45 | 45 | 3.80 | .15 | 38 | 38 | 0.71 | .70 | 57 | 57 | 0.55 | .76 |
| DRB3-5 | ||||||||||||
| DRB3*0101 | 2 | 6 | 2.00 | — | — | — | — | — | 4 | 10 | 2.57 | .54 |
| DRB3*0202 | 7 | 5 | 0.33 | — | 5 | 5 | 0.00 | — | 8 | 5 | 0.69 | — |
| DRB4*0101 | 7 | 13 | 1.80 | — | 5 | 13 | 3.56 | — | 16 | 13 | 0.31 | — |
| DRB5*0101 | 16 | 6 | 4.55 | .16 | 16 | 5 | 5.76 | .08 | 12 | 15 | 0.33 | — |
| All others‡ | 5 | 7 | — | — | 5 | 8 | — | — | 11 | 8 | — | — |
| Total | 37 | 37 | 7.20 | .13 | 31 | 31 | 7.51 | .11 | 51 | 51 | 3.50 | .48 |
| TAP1 Ile333Val | ||||||||||||
| Ile | 14 | 6 | 3.20 | .07 | 12 | 3 | 5.40 | .02 | 15 | 13 | 0.14 | .71 |
| TAP1 Asp637Gly | ||||||||||||
| Asp | 7 | 6 | 0.08 | .78 | 5 | 4 | 0.11 | .74 | 14 | 7 | 2.33 | .13 |
| TAP2 Ile379Val | ||||||||||||
| Ile | 5 | 5 | 0.00 | > .99 | 3 | 5 | 0.50 | .48 | 9 | 3 | 3.00 | .08 |
| TAP2 Ala665Thr | ||||||||||||
| Ala | 5 | 4 | 0.11 | .74 | 3 | 4 | 0.14 | .71 | 5 | 7 | 0.33 | .57 |
Noncandidate alleles either were not significantly associated with sporadic Hodgkin disease or were not evaluated in the study by Klitz et al.16
TAP indicates transporter associated with antigen processing. Other abbreviations are explained in Table 1.
Includes full siblings and half siblings of HD patients.
Significance points for χ2n-1distribution for all alleles (“Total”) at a locus tested simultaneously, and for a χ21 distribution for the largest component with the use of P values adjusted by the method of Bonferroni.
All others include candidate alleles, alleles without power to test, and uninformative typings, which were grouped into a single category.