Table 1. Transmission-disequilibrium... | American Society of Hematology

Table 1.

Transmission-disequilibrium test results for linkage between familial Hodgkin disease and candidate alleles at HLA class II and transporter associated with antigen processing loci, National Cancer Institute, Bethesda, MD, 1978-1993

	All familial HD (n = 28)				Familial NSHD only (n = 23)				Unaffected siblings (n = 40)^†
	T	NT	χ²	P	T	NT	χ²	P	T	NT	χ²	P
DRB1
^*1501	16	6	4.55	.03	15	5	5.00	.03	12	15	0.33	.57
^*1104	6	2	2.00	.16	6	2	2.00	.16	3	2	0.20	.65
^*0701	2	6	2.00	.16	2	6	2.00	.16	5	7	0.33	.57
DQA1
^*0201	2	6	2.00	.16	2	6	2.00	.16	5	7	0.33	.57
DQB1
^*0602	16	6	4.55	.03	16	5	5.76	.02	12	15	0.33	.57
DRB1-DQA1-DQB1
^1501-^0102-^*0602	16	6	4.55	.03	16	5	5.76	.02	12	15	0.33	.57
^1104-^0501-^*0301	6	2	2.00	.16	6	2	2.00	.16	3	2	0.20	.65
^1400-^0101-^*0503	3	1	1.00	.32	1	1	0.00	1.00	2	5	1.29	.26

	All familial HD (n = 28)				Familial NSHD only (n = 23)				Unaffected siblings (n = 40)^†
	T	NT	χ²	P	T	NT	χ²	P	T	NT	χ²	P
DRB1
^*1501	16	6	4.55	.03	15	5	5.00	.03	12	15	0.33	.57
^*1104	6	2	2.00	.16	6	2	2.00	.16	3	2	0.20	.65
^*0701	2	6	2.00	.16	2	6	2.00	.16	5	7	0.33	.57
DQA1
^*0201	2	6	2.00	.16	2	6	2.00	.16	5	7	0.33	.57
DQB1
^*0602	16	6	4.55	.03	16	5	5.76	.02	12	15	0.33	.57
DRB1-DQA1-DQB1
^1501-^0102-^*0602	16	6	4.55	.03	16	5	5.76	.02	12	15	0.33	.57
^1104-^0501-^*0301	6	2	2.00	.16	6	2	2.00	.16	3	2	0.20	.65
^1400-^0101-^*0503	3	1	1.00	.32	1	1	0.00	1.00	2	5	1.29	.26

Candidate alleles are those for which statistically significant associations with sporadic Hodgkin disease were reported by Klitz et al.16

T indicates number of transmitted alleles; NT, number of nontransmitted alleles; HD, Hodgkin disease; and NSHD, nodular sclerosis Hodgkin disease.

†

Includes full siblings and half siblings of HD patients.

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