Oncogene products detectable immunocytochemically in neoplastic hemopoietic cells for which no clinical applications have been defined
| Oncogene . | Genetic abnormality . | Protein product(s) . | Localization in normal tissue . | Studies of neoplastic hemopoietic cells . |
|---|---|---|---|---|
| c-MYC | Fuses to Ig genes in t(8;14), t(2;8), and t(8;22) | MYC protein dimerizes with MAX and binds to DNA | Widely distributed283-285 | Widely expressed in hemopoietic neoplasms; correlation with tumor grade in lymphoma claimed283 286 but not confirmed |
| BCR andABL | t(9;22) creates a hybrid gene | ABL:nuclear kinase; BCR: DNA-binding protein with kinase domain | ABL: present in many cell types, ? nuclear, ? cytoplasmic287-289; BCR: in cytoplasm of many cells290,291 | Several antibody-based studies of BCR-ABL,264,265 288-290 but no diagnostic applications |
| MLL (HRX) | A variety of translocations fuse MLL to other genes | DNA-binding protein, homologous to trithorax in Drosophila | Ubiquitous nuclear expression with tendency to localize to small dotlike structures292 | Chimeric proteins do not differ in immunocytochemical staining from wild-type MLL (HRX)292 |
| E2A | E2A fuses to PBX and HLF in t(1;19) and t(17;19), respectively | Transcription factors | Limited data | Reported that antibodies specific for E2A-PBX junction can be used in diagnosis of leukemia,268 293 but no subsequent studies |
| Oncogene . | Genetic abnormality . | Protein product(s) . | Localization in normal tissue . | Studies of neoplastic hemopoietic cells . |
|---|---|---|---|---|
| c-MYC | Fuses to Ig genes in t(8;14), t(2;8), and t(8;22) | MYC protein dimerizes with MAX and binds to DNA | Widely distributed283-285 | Widely expressed in hemopoietic neoplasms; correlation with tumor grade in lymphoma claimed283 286 but not confirmed |
| BCR andABL | t(9;22) creates a hybrid gene | ABL:nuclear kinase; BCR: DNA-binding protein with kinase domain | ABL: present in many cell types, ? nuclear, ? cytoplasmic287-289; BCR: in cytoplasm of many cells290,291 | Several antibody-based studies of BCR-ABL,264,265 288-290 but no diagnostic applications |
| MLL (HRX) | A variety of translocations fuse MLL to other genes | DNA-binding protein, homologous to trithorax in Drosophila | Ubiquitous nuclear expression with tendency to localize to small dotlike structures292 | Chimeric proteins do not differ in immunocytochemical staining from wild-type MLL (HRX)292 |
| E2A | E2A fuses to PBX and HLF in t(1;19) and t(17;19), respectively | Transcription factors | Limited data | Reported that antibodies specific for E2A-PBX junction can be used in diagnosis of leukemia,268 293 but no subsequent studies |