Gene products involved in leukemia and lymphoma
| Genetic anomaly . | Genes . | Disease . |
|---|---|---|
| Activation of quiescent genes | ||
| t(11;14)(q13;q32) | BCL-1and IgH | Mantle cell lymphoma |
| t(14;18)(q32;q21) | BCL-2 andIgH | Follicular lymphoma |
| Miscellaneous anomalies involving 3q27 | BCL-6 | Diffuse large B-cell lymphoma |
| t(1;14)(p32;q11) and del(14)(q11;q32) | TAL-1 andTCRδ or SIL | T-cell acute lymphoblastic leukemia |
| t(2;8)(p12;q24) and variants | c-MYC andIgH or IgL | Burkitt lymphoma |
| t(6;14)(q25;p32) | MUM1/IRF4 andIgH | Myeloma |
| t(8;14)(p13;q32) | PAX-5 (BSAP) | Immunocytoma |
| Creation of fusion genes | ||
| t(15;17)(q22;q21), t(5;17)(q32;q21), t(11;17)(q13;q21) | RARα, PML, PLZF, NPM, orNuMA | Acute promyelocytic leukemia |
| t(9;22)(q34;q11) | BCR and ABL | Chronic myeloid/acute lymphoblastic leukemia |
| Miscellaneous anomalies involving 11q23 | MLL (HRX) | Acute leukemia |
| t(1;19)(q23;p13) and t(17;19)(q22;p13) | E2A andPBX or HLF | B-cell acute lymphoblastic leukemia |
| t(2;5)(p23;q35) and variants | NPM, ALK | Anaplastic large cell lymphoma |
| t(3;5)(q25.1;q34) | NPM, MLF1 | Myelodysplastic syndrome/acute myeloid leukemia |
| Genetic anomaly . | Genes . | Disease . |
|---|---|---|
| Activation of quiescent genes | ||
| t(11;14)(q13;q32) | BCL-1and IgH | Mantle cell lymphoma |
| t(14;18)(q32;q21) | BCL-2 andIgH | Follicular lymphoma |
| Miscellaneous anomalies involving 3q27 | BCL-6 | Diffuse large B-cell lymphoma |
| t(1;14)(p32;q11) and del(14)(q11;q32) | TAL-1 andTCRδ or SIL | T-cell acute lymphoblastic leukemia |
| t(2;8)(p12;q24) and variants | c-MYC andIgH or IgL | Burkitt lymphoma |
| t(6;14)(q25;p32) | MUM1/IRF4 andIgH | Myeloma |
| t(8;14)(p13;q32) | PAX-5 (BSAP) | Immunocytoma |
| Creation of fusion genes | ||
| t(15;17)(q22;q21), t(5;17)(q32;q21), t(11;17)(q13;q21) | RARα, PML, PLZF, NPM, orNuMA | Acute promyelocytic leukemia |
| t(9;22)(q34;q11) | BCR and ABL | Chronic myeloid/acute lymphoblastic leukemia |
| Miscellaneous anomalies involving 11q23 | MLL (HRX) | Acute leukemia |
| t(1;19)(q23;p13) and t(17;19)(q22;p13) | E2A andPBX or HLF | B-cell acute lymphoblastic leukemia |
| t(2;5)(p23;q35) and variants | NPM, ALK | Anaplastic large cell lymphoma |
| t(3;5)(q25.1;q34) | NPM, MLF1 | Myelodysplastic syndrome/acute myeloid leukemia |