Table 2. Sialidase activity and total... | American Society of Hematology

Table 2.

Sialidase activity and total sialic acid content in erythrocyte resealed vesicles from controls and type 2 diabetic patients

	Controls (95 subjects)	Diabetic patients (117 subjects)
Sialidase activity, μU/mg protein
Acidic sialidase	6.2 ± 2.0	11.2 ± 3.7^†
	(2.7-11.7)	(3.3-27.3)
Neutral sialidase	10.5 ± 3.5	8.2 ± 4.0^†
	(3.0-23)	(1.7-24.8)
Acidic–neutral sialidase ratio	0.6 ± 0.2	1.5 ± 0.5^†
	(0.2-1.2)	(0.35-2.71)
Total sialic acid content,^* μg/mg protein	48.9 ± 10.6	81.3 ± 19.3^†
	(30.7-69.1)	(44.9-13.4)

	Controls (95 subjects)	Diabetic patients (117 subjects)
Sialidase activity, μU/mg protein
Acidic sialidase	6.2 ± 2.0	11.2 ± 3.7^†
	(2.7-11.7)	(3.3-27.3)
Neutral sialidase	10.5 ± 3.5	8.2 ± 4.0^†
	(3.0-23)	(1.7-24.8)
Acidic–neutral sialidase ratio	0.6 ± 0.2	1.5 ± 0.5^†
	(0.2-1.2)	(0.35-2.71)
Total sialic acid content,^* μg/mg protein	48.9 ± 10.6	81.3 ± 19.3^†
	(30.7-69.1)	(44.9-13.4)

The data are expressed as mean ± SD. Ranges are reported in parentheses.

Total sialic acid includes lipid- and protein-bound content.

P < .001, diabetic patients versus controls.