Table 1.

Chemotherapy courses and drug doses in the GIMEMA ALL 0288 randomized trial

CourseRouteDosageDays
Prephase    
 Prednisone PO 20 to 60 mg/m2 Day −7 to −1  
Induction phase I    
 Cyclophosphamide IV 800 mg/m2 Day 1, 2  
 Daunorubicin IV 40 mg/m2 Day 1, 8, 15, 22  
 Vincristine IV 2 mg/m2 Day 1, 8, 15, 22  
 Prednisone PO 60 mg/m2 Day 1-14  
  40 mg/m2 Day 15-31  
 L-asparaginase SC 6000 U/m2 Day 22-31 
Salvage    
 Cytosine arabinoside CI 1000 mg/m2 Day 33-36  
 Mitoxantrone IV 6 mg/m2 Day 33-36  
 Prednisone PO 40 mg/m2 Day 32-39  
Induction phase II    
 Vincristine IV 2 mg/m2 Day 32 
 Mitoxantrone IV 10 mg/m2 Day 32-34 
 Prednisone PO 40 mg/m2 Day 32-39 
Intensification    
 L-VAMP × 3 courses    
  Vincristine IV 1.5 mg/m2 Day 1  
  Methotrexate CI 1000 mg/m2 Day 1  
  Cytosine arabinoside IV 100 mg/m2 Day 1  
  Cytosine arabinoside CI 400 mg/m2 Day 1  
  Dexamethasone IV 10 mg/m2 Day 1-5  
 VM-26 + CA × 4 doses    
  VM-26 IV 165 mg/m2 Day 1, 5, 9, 13  
  Cytosine arabinoside IV 300 mg/m2 Day 1, 5, 9, 13  
Consolidation: every course × 3    
 A    
  Cyclophosphamide IV 800 mg/m2 Day 1  
  Cytosine arabinoside SC 75 mg/m2 Day 3-10 
 B    
  Vincristine IV 1.5 mg/m2 Day 1  
  Daunorubicin IV 40 mg/m2 Day 1  
  Prednisone PO 40 mg/m2 Day 1-7 
 C    
  Vincristine IV 1.5 mg/m2 Day 8  
  Mitoxantrone IV 10 mg/m2 Day 8-10  
  Prednisone PO 40 mg/m2 Day 8-15 
 D    
  VM-26 IV 165 mg/m2 Day 1, 5  
  Cytosine arabinoside IV 300 mg/m2 Day 1, 5  
 E    
  L-VAMP    
Maintenance 5-wk courses × 2 y    
 Methotrexate IM 30 mg/m2 Day 1, 8, 15  
 6-Mercaptopurine PO 70 mg/m2 Day 1-21  
 Vincristine IV 1.5 mg/m2 Day 22, 29  
 Prednisone PO 40 mg/m2 Day 22-36  
CNS prophylaxis × 16 doses    
 Methotrexate IT 12 mg  
 Methylprednisolone IT 40 mg  
CourseRouteDosageDays
Prephase    
 Prednisone PO 20 to 60 mg/m2 Day −7 to −1  
Induction phase I    
 Cyclophosphamide IV 800 mg/m2 Day 1, 2  
 Daunorubicin IV 40 mg/m2 Day 1, 8, 15, 22  
 Vincristine IV 2 mg/m2 Day 1, 8, 15, 22  
 Prednisone PO 60 mg/m2 Day 1-14  
  40 mg/m2 Day 15-31  
 L-asparaginase SC 6000 U/m2 Day 22-31 
Salvage    
 Cytosine arabinoside CI 1000 mg/m2 Day 33-36  
 Mitoxantrone IV 6 mg/m2 Day 33-36  
 Prednisone PO 40 mg/m2 Day 32-39  
Induction phase II    
 Vincristine IV 2 mg/m2 Day 32 
 Mitoxantrone IV 10 mg/m2 Day 32-34 
 Prednisone PO 40 mg/m2 Day 32-39 
Intensification    
 L-VAMP × 3 courses    
  Vincristine IV 1.5 mg/m2 Day 1  
  Methotrexate CI 1000 mg/m2 Day 1  
  Cytosine arabinoside IV 100 mg/m2 Day 1  
  Cytosine arabinoside CI 400 mg/m2 Day 1  
  Dexamethasone IV 10 mg/m2 Day 1-5  
 VM-26 + CA × 4 doses    
  VM-26 IV 165 mg/m2 Day 1, 5, 9, 13  
  Cytosine arabinoside IV 300 mg/m2 Day 1, 5, 9, 13  
Consolidation: every course × 3    
 A    
  Cyclophosphamide IV 800 mg/m2 Day 1  
  Cytosine arabinoside SC 75 mg/m2 Day 3-10 
 B    
  Vincristine IV 1.5 mg/m2 Day 1  
  Daunorubicin IV 40 mg/m2 Day 1  
  Prednisone PO 40 mg/m2 Day 1-7 
 C    
  Vincristine IV 1.5 mg/m2 Day 8  
  Mitoxantrone IV 10 mg/m2 Day 8-10  
  Prednisone PO 40 mg/m2 Day 8-15 
 D    
  VM-26 IV 165 mg/m2 Day 1, 5  
  Cytosine arabinoside IV 300 mg/m2 Day 1, 5  
 E    
  L-VAMP    
Maintenance 5-wk courses × 2 y    
 Methotrexate IM 30 mg/m2 Day 1, 8, 15  
 6-Mercaptopurine PO 70 mg/m2 Day 1-21  
 Vincristine IV 1.5 mg/m2 Day 22, 29  
 Prednisone PO 40 mg/m2 Day 22-36  
CNS prophylaxis × 16 doses    
 Methotrexate IT 12 mg  
 Methylprednisolone IT 40 mg  

PO indicates orally; IV, intravenously, SC, subcutaneously; CI, continuous infusion; IM, intramuscularly; IT, intrathecally. A, B, C, D, and E are abbreviations of each course.

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