Table 1.

VWF multimer analyses

SamplesLow–molecular-weight multimers, %High–molecular-weight multimers, %
Normal plasma (control) 46 54  
Lot AP3034A 54 46  
Lot AP3034A + heat treatment 60 40  
Lot AP3020 61 39  
Lot AP3020 + heat treatment 65 36  
Lot AP3018A 63 37  
Lot AP3018A + heat treatment 63 37 
SamplesLow–molecular-weight multimers, %High–molecular-weight multimers, %
Normal plasma (control) 46 54  
Lot AP3034A 54 46  
Lot AP3034A + heat treatment 60 40  
Lot AP3020 61 39  
Lot AP3020 + heat treatment 65 36  
Lot AP3018A 63 37  
Lot AP3018A + heat treatment 63 37 

High–molecular-weight multimers were determined from densitometric scans and were defined as the area under the 5 molecular peaks from the high–molecular-weight end of the scan as described by Cumming et al.20 

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