Table 4. Episodes of grade 3 and 4... | American Society of Hematology

Table 4.

Episodes of grade 3 and 4 toxicities on CCG-1891

	DI		DIVPI		DDI
	No. episodes	Episodes per 100 patient days^4-150	No. episodes	Episodes per 100 patient days^4-150	No. episodes	Episodes per 100 patient days^4-150
Hepatic
SGOT	69	0.023	71	0.025	59	0.020
SGPT	205	0.068	213	0.074	240	0.083
Alkaline phosphatase	9	0.003	16	0.006	6	0.002
Bilirubin	33	0.011	35	0.012	27	0.009
Pancreatic	0	0.0	2	0.001	8	0.003
Renal	3	0.001	0	0.0	4	0.001
Gastrointestinal	11	0.004	10	0.004	24	0.008
Pulmonary	6	0.002	9	0.003	10	0.003
Cardiac	0	0.0	0	0.0	3	0.001
Nervous system
Peripheral	4	0.001	8	0.003	7	0.002
Central	1	0.0	2	0.001	2	0.001
Dermatological	8	0.003	12	0.004	12	0.004
Blood coagulation	1	0.0	4	0.001	16	0.006
Infection	21	0.007	20	0.007	46	0.016

	DI		DIVPI		DDI
	No. episodes	Episodes per 100 patient days^4-150	No. episodes	Episodes per 100 patient days^4-150	No. episodes	Episodes per 100 patient days^4-150
Hepatic
SGOT	69	0.023	71	0.025	59	0.020
SGPT	205	0.068	213	0.074	240	0.083
Alkaline phosphatase	9	0.003	16	0.006	6	0.002
Bilirubin	33	0.011	35	0.012	27	0.009
Pancreatic	0	0.0	2	0.001	8	0.003
Renal	3	0.001	0	0.0	4	0.001
Gastrointestinal	11	0.004	10	0.004	24	0.008
Pulmonary	6	0.002	9	0.003	10	0.003
Cardiac	0	0.0	0	0.0	3	0.001
Nervous system
Peripheral	4	0.001	8	0.003	7	0.002
Central	1	0.0	2	0.001	2	0.001
Dermatological	8	0.003	12	0.004	12	0.004
Blood coagulation	1	0.0	4	0.001	16	0.006
Infection	21	0.007	20	0.007	46	0.016

Data shown are frequencies of grade 3 or 4 nonhematological toxicities, enumerated from the beginning of the second interim maintenance (DDI) or maintenance (DI and DIVPI).

SGOT indicates serum glutamic-oxaloacetic transaminase; SGPT, serum glutamic-pyruvic transaminase. See Table 1 footnote for other abbreviations.

F4-150

Patient days were defined as the total number of days spent on therapy for all patients entering interim maintenance 2 (DDI) or maintenance (DI and DIVPI). Episodes per 100 patient days were calculated as number of episodes per total patient days divided by 100.

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