Agonist-induced calcium mobilization in neutrophils
| Agonist . | Healthy donors Mean; range (n) . | Patient (nM) . |
|---|---|---|
| fMLP (0.1 μM) | 171; 38-531 (24) | 121 |
| fMLP (1 μM) | 187; 49-663 (25) | 100 |
| fMLP (10 μM) | 226; 61-501 (25) | 138 |
| ADP (50 μM) | 41; 18-100 (21) | 40 |
| ADP (200 μM) | 127; 14-479 (24) | 165 |
| PAF (0.1 μM) | 146; 25-263 (23) | 37 |
| PAF (1 μM) | 191; 38-320 (22) | 126 |
| C5a (1 μM) | 76; 18-144 (18) | 40 |
| C5a (5 μM) | 146; 38-416 (19) | 100 |
| IL-8 (1 nM) | 126; 41-307 (20) | 51 |
| IL-8 (5 nM) | 132; 38-238 (18) | 79 |
| LTB4 (0.1 μg/mL) | 175; 139-234 (4) | 146 |
| LTB4 (0.25 μg/mL) | 211; 139-301 (4) | 99 |
| Agonist . | Healthy donors Mean; range (n) . | Patient (nM) . |
|---|---|---|
| fMLP (0.1 μM) | 171; 38-531 (24) | 121 |
| fMLP (1 μM) | 187; 49-663 (25) | 100 |
| fMLP (10 μM) | 226; 61-501 (25) | 138 |
| ADP (50 μM) | 41; 18-100 (21) | 40 |
| ADP (200 μM) | 127; 14-479 (24) | 165 |
| PAF (0.1 μM) | 146; 25-263 (23) | 37 |
| PAF (1 μM) | 191; 38-320 (22) | 126 |
| C5a (1 μM) | 76; 18-144 (18) | 40 |
| C5a (5 μM) | 146; 38-416 (19) | 100 |
| IL-8 (1 nM) | 126; 41-307 (20) | 51 |
| IL-8 (5 nM) | 132; 38-238 (18) | 79 |
| LTB4 (0.1 μg/mL) | 175; 139-234 (4) | 146 |
| LTB4 (0.25 μg/mL) | 211; 139-301 (4) | 99 |
Shown are the increase in cytoplasmic Ca++concentration over the basal level upon activation.
The patient results are representative of 2 separate studies.