Table 1. Percent changes over baseline... | American Society of Hematology

Table 1.

Percent changes over baseline of sEPCR, protein C antigen, and INR mean values in 6 healthy subjects starting warfarin treatment

Day of Study	0	1	2	3	4	5	8	9	10	11	12	15
Dose of Warfarin, mg/d	10	10	7.3 (4.1-10.4)	6.3 (2.6-9.9)	5.8 (2.5-9.1)	6.7 (2.7-10.6)	6.7 (2.7-10.6)	—	—	—	—	—
sEPCR	100	93 (82-105)	89 (77-102)	77 (67-89)^*	74 (63-87)^*	71 (57-88)^*	67 (51-87)^*	69 (50-94)^*	80 (53-120)	80 (66-98)	90 (76-106)	97 (82-114)
PC:Ag	100	65 (43-99)	42 (25-70)^*	31 (18-53)^*	32 (23-44)^†	28 (19-44)^†	33 (27-41)^‡	42 (35-50)^‡	49 (38-63)^*	77 (55-106)	86 (57-128)	98 (75-126)
INR	0.95	1.13	1.57	1.99	2.17	2.20	2.34	1.90	1.39	1.13	1.01	0.94
	(0.90-0.99)	(1.01-1.27)	(1.16-2.13)	(1.47-2.69)^*	(1.73-2.73)^‡	(1.70-2.85)^†	(1.69-3.23)^†	(1.41-2.57)^†	(1.10-1.75)^*	(0.99-1.28)	(0.96-1.07)	(0.90-0.98)

Day of Study	0	1	2	3	4	5	8	9	10	11	12	15
Dose of Warfarin, mg/d	10	10	7.3 (4.1-10.4)	6.3 (2.6-9.9)	5.8 (2.5-9.1)	6.7 (2.7-10.6)	6.7 (2.7-10.6)	—	—	—	—	—
sEPCR	100	93 (82-105)	89 (77-102)	77 (67-89)^*	74 (63-87)^*	71 (57-88)^*	67 (51-87)^*	69 (50-94)^*	80 (53-120)	80 (66-98)	90 (76-106)	97 (82-114)
PC:Ag	100	65 (43-99)	42 (25-70)^*	31 (18-53)^*	32 (23-44)^†	28 (19-44)^†	33 (27-41)^‡	42 (35-50)^‡	49 (38-63)^*	77 (55-106)	86 (57-128)	98 (75-126)
INR	0.95	1.13	1.57	1.99	2.17	2.20	2.34	1.90	1.39	1.13	1.01	0.94
	(0.90-0.99)	(1.01-1.27)	(1.16-2.13)	(1.47-2.69)^*	(1.73-2.73)^‡	(1.70-2.85)^†	(1.69-3.23)^†	(1.41-2.57)^†	(1.10-1.75)^*	(0.99-1.28)	(0.96-1.07)	(0.90-0.98)

Values are means (95% confidence intervals). All comparisons were adjusted according to the Bonferroni method.

P < .05 compared with baseline values.

P ≤ .01 compared with baseline values.

P < .001 compared with baseline values.