Steady-state hematology of mice that received transplants and reconstituted with donor STATab−/− bone marrow or fetal liver cells
| Hematologic parameter* . | STAT5ab+/+ donor . | STAT5ab−/− donor . | % Control . | P . |
|---|---|---|---|---|
| Bone marrow transplantation | ||||
| White blood cells/μL | 15 251 ± 1 849 | 4 145 ± 742 | 27 | < .001 |
| Absolute lymphocyte count/μL | 12 141 ± 2 164 | 2 683 ± 778 | 22 | < .001 |
| Absolute neutrophil count/μL | 2 260 ± 598 | 984 ± 41 | 44 | < .001 |
| Absolute monocyte count/μL | 851 ± 242 | 478 ± 176 | 56 | .01 |
| Hematocrit | 44 ± 1 | 38 ± 1 | 86 | < .001 |
| Fetal liver transplantation | ||||
| White blood cells/μL | 12 679 ± 3 049 | 5 741 ± 1 917 | 45 | < .001 |
| Absolute lymphocyte count/μL | 9 619 ± 3 082 | 3 012 ± 1 764 | 31 | < .001 |
| Absolute neutrophil count/μL | 2 490 ± 705 | 1 686 ± 1 379 | 68 | .19 |
| Absolute monocyte count/μL | 753 ± 384 | 930 ± 355 | 123 | .39 |
| Hematocrit | 44 ± 2 | 38 ± 4 | 86 | .004 |
| Hematologic parameter* . | STAT5ab+/+ donor . | STAT5ab−/− donor . | % Control . | P . |
|---|---|---|---|---|
| Bone marrow transplantation | ||||
| White blood cells/μL | 15 251 ± 1 849 | 4 145 ± 742 | 27 | < .001 |
| Absolute lymphocyte count/μL | 12 141 ± 2 164 | 2 683 ± 778 | 22 | < .001 |
| Absolute neutrophil count/μL | 2 260 ± 598 | 984 ± 41 | 44 | < .001 |
| Absolute monocyte count/μL | 851 ± 242 | 478 ± 176 | 56 | .01 |
| Hematocrit | 44 ± 1 | 38 ± 1 | 86 | < .001 |
| Fetal liver transplantation | ||||
| White blood cells/μL | 12 679 ± 3 049 | 5 741 ± 1 917 | 45 | < .001 |
| Absolute lymphocyte count/μL | 9 619 ± 3 082 | 3 012 ± 1 764 | 31 | < .001 |
| Absolute neutrophil count/μL | 2 490 ± 705 | 1 686 ± 1 379 | 68 | .19 |
| Absolute monocyte count/μL | 753 ± 384 | 930 ± 355 | 123 | .39 |
| Hematocrit | 44 ± 2 | 38 ± 4 | 86 | .004 |
STAT indicates signal transducers and activators of transcription.
Sample sizes consisted of 6 to 8 mice per group analyzed 7 to 11 weeks after transplantation. Mice used for analysis appeared to be healthy and did not show signs of sickness related to splenomegaly disease. The % control is calculated for the average STAT5ab−/− relative to the STAT5ab+/+hematology values. P values were calculated by using the Student 2-tailed t test.