Analysis of mice that received transplants of wild-type FLT3 or FLT3-ITD-transduced bone marrow
| Construct . | No. of mice . | WBC count, per μL (median) . | Spleen weight, mg (median) . | Phenotype . |
|---|---|---|---|---|
| Wt-FLT3 | 6 | 3.5-5.5 × 103 (5 × 103) | 100-171 (113) | Normal |
| FLT3-ITD/51 | 8 | 28-145 × 103 (36 × 103) | 300-1000 (800) | Myeloproliferation |
| FLT3-ITD/78 | 6 | 6.5-129 × 103 (75 × 103) | 250-900 (670) | Myeloproliferation |
| Construct . | No. of mice . | WBC count, per μL (median) . | Spleen weight, mg (median) . | Phenotype . |
|---|---|---|---|---|
| Wt-FLT3 | 6 | 3.5-5.5 × 103 (5 × 103) | 100-171 (113) | Normal |
| FLT3-ITD/51 | 8 | 28-145 × 103 (36 × 103) | 300-1000 (800) | Myeloproliferation |
| FLT3-ITD/78 | 6 | 6.5-129 × 103 (75 × 103) | 250-900 (670) | Myeloproliferation |
The construct used is listed in column 1, followed by the number of mice analyzed in column 2. The phenotype is listed as normal or myeloproliferation based on the histologic and immunologic phenotype.