Table 3. Genotypic and phenotypic... | American Society of Hematology

Table 3.

Genotypic and phenotypic features of B-CLL tumors with wild-type ATM/TP53

Patient	ATM gene	TP53gene	p53/MDM2/p21 induction	Nearest VH/D/J gene	% Homology	Stage	Th
B-CLL47	WT	WT	Normal	V4-34	95.5	A	No
				D5-5
B-CLL48	WT	WT	Normal	V1-03	81.9	A	No
				D2-2
B-CLL13	WT	WT	Normal	V3-30.3	99.6	C	No
				D3-3/J4
B-CLL15	WT	WT	Normal	V1-58	92.7	B	No
				D6-6/J4
B-CLL19	WT	WT	Normal	V3-30.3	89.9	A	No
				D3-3
B-CLL49	WT	WT	Normal	V5-11	95	A	No
				D21-7/J4
B-CLL20	WT	WT	Normal	V1-02	99.3	C	C
				D3-22/J4
B-CLL50	WT	WT	Normal	V1-12	95	C	C
B-CLL51	WT	WT	Normal	V3-23	98.6	A	No
				D4-17
B-CLL52	WT	WT	Normal	V1-69	94.8	A	No
				D3-16
B-CLL53	WT	WT	Normal	V3-21	97.3	B	No
				D3-9
B-CLL54	WT	WT	Normal	V3-74	93.5	C	F
				D5-12
B-CLL55^3-150	WT	WT	Normal	V3-74	100	C	E/C/F
	LOH			D3-10
B-CLL56	WT	WT	Normal	V4-41	92.1	A	No
				D1-7
B-CLL57	WT	WT	Normal	V1-08	90	A	No
				D3-10
B-CLL58^3-150	WT	WT	Normal	V4-15	97.9	C	E/C/F
	LOH			D5-24
B-CLL59	WT	WT	Normal	V3-30.3	98.2	B	C
				D3-3
B-CLL60	WT	WT	Normal	V3-21	97.2	C	C
				D4-4
B-CLL61	WT	WT	Normal	V3-23	95	A	No
B-CLL68	WT	WT	ND	V3-43	90	A	No
B-CLL62	WT	WT	ND	V3-33	96.8	A	No
B-CLL63	WT	WT	ND	V3-48	89.6	C	F
				D3-9/J6
B-CLL29	WT	WT	ND	V3-23	94.1	A	No
B-CLL11	WT	WT	ND	VDJ ns	ns	C	C/CHOP
B-CLL64	WT	WT	ND	V1-2	99.5	A	No
				D3-10
B-CLL10	WT	WT	ND	V1-02	99.6	B	C/P
				D3-3
B-CLL67	WT	WT	ND	V4-39	95.3	B	E/C
				D2-9
B-CLL65	WT	WT	ND	V3-72	91.9	A	C
				D3-9

Patient	ATM gene	TP53gene	p53/MDM2/p21 induction	Nearest VH/D/J gene	% Homology	Stage	Th
B-CLL47	WT	WT	Normal	V4-34	95.5	A	No
				D5-5
B-CLL48	WT	WT	Normal	V1-03	81.9	A	No
				D2-2
B-CLL13	WT	WT	Normal	V3-30.3	99.6	C	No
				D3-3/J4
B-CLL15	WT	WT	Normal	V1-58	92.7	B	No
				D6-6/J4
B-CLL19	WT	WT	Normal	V3-30.3	89.9	A	No
				D3-3
B-CLL49	WT	WT	Normal	V5-11	95	A	No
				D21-7/J4
B-CLL20	WT	WT	Normal	V1-02	99.3	C	C
				D3-22/J4
B-CLL50	WT	WT	Normal	V1-12	95	C	C
B-CLL51	WT	WT	Normal	V3-23	98.6	A	No
				D4-17
B-CLL52	WT	WT	Normal	V1-69	94.8	A	No
				D3-16
B-CLL53	WT	WT	Normal	V3-21	97.3	B	No
				D3-9
B-CLL54	WT	WT	Normal	V3-74	93.5	C	F
				D5-12
B-CLL55^3-150	WT	WT	Normal	V3-74	100	C	E/C/F
	LOH			D3-10
B-CLL56	WT	WT	Normal	V4-41	92.1	A	No
				D1-7
B-CLL57	WT	WT	Normal	V1-08	90	A	No
				D3-10
B-CLL58^3-150	WT	WT	Normal	V4-15	97.9	C	E/C/F
	LOH			D5-24
B-CLL59	WT	WT	Normal	V3-30.3	98.2	B	C
				D3-3
B-CLL60	WT	WT	Normal	V3-21	97.2	C	C
				D4-4
B-CLL61	WT	WT	Normal	V3-23	95	A	No
B-CLL68	WT	WT	ND	V3-43	90	A	No
B-CLL62	WT	WT	ND	V3-33	96.8	A	No
B-CLL63	WT	WT	ND	V3-48	89.6	C	F
				D3-9/J6
B-CLL29	WT	WT	ND	V3-23	94.1	A	No
B-CLL11	WT	WT	ND	VDJ ns	ns	C	C/CHOP
B-CLL64	WT	WT	ND	V1-2	99.5	A	No
				D3-10
B-CLL10	WT	WT	ND	V1-02	99.6	B	C/P
				D3-3
B-CLL67	WT	WT	ND	V4-39	95.3	B	E/C
				D2-9
B-CLL65	WT	WT	ND	V3-72	91.9	A	C
				D3-9

B-CLLs 55 and 58 had 11q deletion and LOH acrossATM region.

For abbreviations, see Table 1.