Cox proportional hazard and time-dependent regression analysis for overall survival
| Variable . | n . | Parameter estimate . | Relative risk . | 95% CI . | P . |
|---|---|---|---|---|---|
| Univariate analysis | |||||
| Age, y | |||||
| 60 or younger vs older than 60 | 63 | −1.09 | 0.34 | 0.17-0.66 | .002 |
| AML type | |||||
| de novo vs secondary | 63 | −0.88 | 0.41 | 0.21-0.80 | .009 |
| Cytogenetic status | |||||
| favorable vs intermediate or unfavorable | 62 | −2.41 | 0.09 | 0.01-0.66 | .018 |
| WBC count | 60 | 0.001 | 1.00 | 1.00-1.01 | .615 |
| Time-dependent covariate models | |||||
| STAT3 (no activity vs activity) | 63 | −1.40 | 0.25 | 0.07-0.88 | .031 |
| STAT3 × time-dependent covariate | 0.18 | 1.20 | 1.07-1.34 | .002 | |
| STAT3 | 63 | −1.57 | 0.21 | 0.06-0.75 | .016 |
| STAT3 × time-dependent covariate | 0.17 | 1.19 | 1.06-1.33 | .003 | |
| Age | −0.92 | 0.40 | 0.20-0.79 | .009 | |
| STAT3 | 62 | −1.42 | 0.24 | 0.06-0.75 | .029 |
| STAT3 × time-dependent covariate | 0.17 | 1.19 | 1.06-1.33 | .003 | |
| AML type | −0.61 | 0.55 | 0.28-1.07 | .077 | |
| STAT3 | 62 | −1.56 | 0.21 | 0.06-0.75 | .016 |
| STAT3 × time-dependent covariate | 0.16 | 1.18 | 1.05-1.32 | .005 | |
| Cytogenetic status | −1.97 | 0.14 | 0.02-1.03 | .054 |
| Variable . | n . | Parameter estimate . | Relative risk . | 95% CI . | P . |
|---|---|---|---|---|---|
| Univariate analysis | |||||
| Age, y | |||||
| 60 or younger vs older than 60 | 63 | −1.09 | 0.34 | 0.17-0.66 | .002 |
| AML type | |||||
| de novo vs secondary | 63 | −0.88 | 0.41 | 0.21-0.80 | .009 |
| Cytogenetic status | |||||
| favorable vs intermediate or unfavorable | 62 | −2.41 | 0.09 | 0.01-0.66 | .018 |
| WBC count | 60 | 0.001 | 1.00 | 1.00-1.01 | .615 |
| Time-dependent covariate models | |||||
| STAT3 (no activity vs activity) | 63 | −1.40 | 0.25 | 0.07-0.88 | .031 |
| STAT3 × time-dependent covariate | 0.18 | 1.20 | 1.07-1.34 | .002 | |
| STAT3 | 63 | −1.57 | 0.21 | 0.06-0.75 | .016 |
| STAT3 × time-dependent covariate | 0.17 | 1.19 | 1.06-1.33 | .003 | |
| Age | −0.92 | 0.40 | 0.20-0.79 | .009 | |
| STAT3 | 62 | −1.42 | 0.24 | 0.06-0.75 | .029 |
| STAT3 × time-dependent covariate | 0.17 | 1.19 | 1.06-1.33 | .003 | |
| AML type | −0.61 | 0.55 | 0.28-1.07 | .077 | |
| STAT3 | 62 | −1.56 | 0.21 | 0.06-0.75 | .016 |
| STAT3 × time-dependent covariate | 0.16 | 1.18 | 1.05-1.32 | .005 | |
| Cytogenetic status | −1.97 | 0.14 | 0.02-1.03 | .054 |
Time-dependent covariate shows how the relative risk associated with constitutive STAT3 activity varies over time.