Table 2.

Treatment outcome

Total
(n = 63)
STAT3+ (n = 28)STAT3(n = 35)P
Induction treatment    .75 
 HIDAC/IDA* 51 22 29 
 Other 12 
Consolidation 46 21 25 .37 
 HIDAC/IDA group 12 
  HIDAC/IDA alone 
  HIDAC/IDA + VP/CY 
  HIDAC/IDA + HIDAC/DNR2-153 
 VP/CY 16 10 
 Other 16 10 
  AlloBMT in first remission 
  AutoPBSCT 
  ADE2-155 
  HIDAC alone 
  7 and 32-154 + HIDAC/DNR 
 None 
AlloBMT relapse/refractory AML/2nd remission 11 NA 
DFS (median, mo) 10.6 8.7 20.6 .01  
Overall survival (median, mo) 14.7 14.0 16.8 .1  
Attainment of CR: 
 Yes 46 21 25 .78 
 No 17 10  
Total
(n = 63)
STAT3+ (n = 28)STAT3(n = 35)P
Induction treatment    .75 
 HIDAC/IDA* 51 22 29 
 Other 12 
Consolidation 46 21 25 .37 
 HIDAC/IDA group 12 
  HIDAC/IDA alone 
  HIDAC/IDA + VP/CY 
  HIDAC/IDA + HIDAC/DNR2-153 
 VP/CY 16 10 
 Other 16 10 
  AlloBMT in first remission 
  AutoPBSCT 
  ADE2-155 
  HIDAC alone 
  7 and 32-154 + HIDAC/DNR 
 None 
AlloBMT relapse/refractory AML/2nd remission 11 NA 
DFS (median, mo) 10.6 8.7 20.6 .01  
Overall survival (median, mo) 14.7 14.0 16.8 .1  
Attainment of CR: 
 Yes 46 21 25 .78 
 No 17 10  

AlloBMT indicates allogeneic bone marrow transplantation; AutoPBSCT, autologous peripheral blood stem cell transplantation; NA, not analyzed; and STAT, signal transducer and activator of transcription proteins.

*

High-dose cytarabine 3 g/m2 every 12 hours for a total of 12 doses (1.5 g/m2 for patients older than 50) and idarubicin 12 mg/m2 daily for 3 consecutive days.

Five patients treated with cytarabine 100 mg/m2 continuous infusion over 7 days, daunorubicin 60 mg/m2 daily for 3 days, etoposide 100 mg/m2 for 3 days; three patients treated with cytarabine 100 mg/m2continuous infusion over 7 days, daunorubicin 45 mg/m2daily for 3 days, etoposide 100 mg/m2 for 3 days, and PSC 833 10 mg/m2 for 3 days; one patient treated with cytarabine 200 mg/m2 continuous infusion over 7 days and daunorubicin 45 mg/m2 daily for 3 days; one patient treated with all-trans retinoic acid 40 mg/m2 every 12 hours and idarubicin 12 mg/m2 every other day for 4 doses; one patient treated with cytarabine 1.5 g/m2 every 12 hours for a total of 12 doses; one patient treated with cytarabine 100 mg/m2 continuous infusion over 7 days.

Etoposide 3.6 g/m2 by continuous infusion and cyclophosphamide 50 mg/kg for 4 days.

F2-153

High-dose cytarabine 2 g/m2 every 12 hours for a total of 8 doses and daunorubicin 45 mg/m2 for 2 days.

F2-155

Cytarabine 100 mg/m2 continuous infusion over 5 days, daunorubicin 60 mg/m2 daily for 2 days, and etoposide 100 mg/m2 for 2 days.

F2-154

Cytarabine 100 mg/m2 continuous infusion over 7 days and daunorubicin 45 mg/m2 daily for 3 days.

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