Treatment outcome
. | Total (n = 63) . | STAT3+ (n = 28) . | STAT3−(n = 35) . | P . |
---|---|---|---|---|
Induction treatment | .75 | |||
HIDAC/IDA* | 51 | 22 | 29 | |
Other† | 12 | 6 | 6 | |
Consolidation | 46 | 21 | 25 | .37 |
HIDAC/IDA group | 12 | 4 | 8 | |
HIDAC/IDA alone | 8 | 2 | 6 | |
HIDAC/IDA + VP/CY‡ | 3 | 1 | 2 | |
HIDAC/IDA + HIDAC/DNR2-153 | 1 | 1 | 0 | |
VP/CY | 16 | 10 | 6 | |
Other | 16 | 6 | 10 | |
AlloBMT in first remission | 2 | 1 | 1 | |
AutoPBSCT | 8 | 3 | 5 | |
ADE2-155 | 2 | 2 | 0 | |
HIDAC alone | 2 | 0 | 2 | |
7 and 32-154 + HIDAC/DNR | 2 | 0 | 2 | |
None | 2 | 1 | 1 | |
AlloBMT relapse/refractory AML/2nd remission | 11 | 5 | 6 | NA |
DFS (median, mo) | 10.6 | 8.7 | 20.6 | .01 |
Overall survival (median, mo) | 14.7 | 14.0 | 16.8 | .1 |
Attainment of CR: | ||||
Yes | 46 | 21 | 25 | .78 |
No | 17 | 7 | 10 |
. | Total (n = 63) . | STAT3+ (n = 28) . | STAT3−(n = 35) . | P . |
---|---|---|---|---|
Induction treatment | .75 | |||
HIDAC/IDA* | 51 | 22 | 29 | |
Other† | 12 | 6 | 6 | |
Consolidation | 46 | 21 | 25 | .37 |
HIDAC/IDA group | 12 | 4 | 8 | |
HIDAC/IDA alone | 8 | 2 | 6 | |
HIDAC/IDA + VP/CY‡ | 3 | 1 | 2 | |
HIDAC/IDA + HIDAC/DNR2-153 | 1 | 1 | 0 | |
VP/CY | 16 | 10 | 6 | |
Other | 16 | 6 | 10 | |
AlloBMT in first remission | 2 | 1 | 1 | |
AutoPBSCT | 8 | 3 | 5 | |
ADE2-155 | 2 | 2 | 0 | |
HIDAC alone | 2 | 0 | 2 | |
7 and 32-154 + HIDAC/DNR | 2 | 0 | 2 | |
None | 2 | 1 | 1 | |
AlloBMT relapse/refractory AML/2nd remission | 11 | 5 | 6 | NA |
DFS (median, mo) | 10.6 | 8.7 | 20.6 | .01 |
Overall survival (median, mo) | 14.7 | 14.0 | 16.8 | .1 |
Attainment of CR: | ||||
Yes | 46 | 21 | 25 | .78 |
No | 17 | 7 | 10 |
AlloBMT indicates allogeneic bone marrow transplantation; AutoPBSCT, autologous peripheral blood stem cell transplantation; NA, not analyzed; and STAT, signal transducer and activator of transcription proteins.
High-dose cytarabine 3 g/m2 every 12 hours for a total of 12 doses (1.5 g/m2 for patients older than 50) and idarubicin 12 mg/m2 daily for 3 consecutive days.
Five patients treated with cytarabine 100 mg/m2 continuous infusion over 7 days, daunorubicin 60 mg/m2 daily for 3 days, etoposide 100 mg/m2 for 3 days; three patients treated with cytarabine 100 mg/m2continuous infusion over 7 days, daunorubicin 45 mg/m2daily for 3 days, etoposide 100 mg/m2 for 3 days, and PSC 833 10 mg/m2 for 3 days; one patient treated with cytarabine 200 mg/m2 continuous infusion over 7 days and daunorubicin 45 mg/m2 daily for 3 days; one patient treated with all-trans retinoic acid 40 mg/m2 every 12 hours and idarubicin 12 mg/m2 every other day for 4 doses; one patient treated with cytarabine 1.5 g/m2 every 12 hours for a total of 12 doses; one patient treated with cytarabine 100 mg/m2 continuous infusion over 7 days.
Etoposide 3.6 g/m2 by continuous infusion and cyclophosphamide 50 mg/kg for 4 days.
High-dose cytarabine 2 g/m2 every 12 hours for a total of 8 doses and daunorubicin 45 mg/m2 for 2 days.
Cytarabine 100 mg/m2 continuous infusion over 5 days, daunorubicin 60 mg/m2 daily for 2 days, and etoposide 100 mg/m2 for 2 days.
Cytarabine 100 mg/m2 continuous infusion over 7 days and daunorubicin 45 mg/m2 daily for 3 days.