Table 1.

IL-12 dose escalation schema

Dose levelNo. of patientsIL-12 dose (ng/kg SQ biw)*
1 6   0† 
2 6  30‡ 
3 9 100‡ 
4 9 300‡ 
5 3 500‡ 
6 6 3001-153 
7 4 5001-153 
Dose levelNo. of patientsIL-12 dose (ng/kg SQ biw)*
1 6   0† 
2 6  30‡ 
3 9 100‡ 
4 9 300‡ 
5 3 500‡ 
6 6 3001-153 
7 4 5001-153 

SQ indicates subcutaneously; biw, biweekly.

*

The rituximab dose was fixed at 375 mg/m2.

†

Patients at dose level 1 received IL-12 at 30 ng/kg beginning on day 29 (eg, after completing rituximab).

‡

Patients received IL-12 beginning on day 16.

F1-153

Patients received IL-12 beginning on day 2.

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