Table 1. Main morphologic changes... | American Society of Hematology

Table 1.

Main morphologic changes detected on bone marrow biopsy of patients before and during STI571 therapy

Patients	Cellularity			Megakaryopoiesis			Fibrosis
Patients	1	2	3	1	2	3	1	2	3
Group 1
1 SB	↑↑↑	↑	N	↑↑	N	N	1	1	0
2 PM	↑↑↑	N	N	↑	N	N	1	0	0
3 ZH	↑↑↑	↑	N	↑↑	↑	N	3	1	0
4 UP	↑↑↑	N	N	↑↑	N	N	1	0	0
5 SJ	↑↑	N	N	↑	N	↑	1	0	0
6 PF	↑	N	N	N	N	N	0	0	0
7 PE	↑	N	N	↑	N	N	1	0	0
8 HJ	↑↑↑	↑	N	↑	↑	N	0	0	0
9 HaJ	↑↑↑	↑	N	↑	N	N	1	0	0
Group 2
1 HL	↑↑↑	N	↑↑	↑↑	N	↑↑↑	2	1	1
2 UB	↑↑↑	↑	↑↑↑	↑↑	N	↑	2	1	1
3 WH	↑↑↑	↑↑	N	↓	↑	N	2	0	0
4 HR	↑↑	N	↑	N	N	↑	1	0	0
5 ER	↑↑↑	↑	↑	↑↑	N	↑	2	0	0
6 WA	↑↑↑	N	N	↑↑	N	N	2	0	0
7 DA	↑↑↑	N	↑	↑	N	N	1	0	0
8 KG	↑↑↑	↑↑↑	N	↑↑	↑↑	N	2	1	0
Group 3
1 PH	↑↑↑	↑↑↑	↑↑	↓↓	↓↓	↓	4	3	3
2 WF	↑↑↑	N	N	↑↑↑	N	N	4	3	0
3 FM	↑↑↑	↑	↑↑	↑↑	N	↑	3	0	0
4 TJ	↑↑↑	↑	↑	↓↓	N	N	1	1	0
5 LK	↑↑↑	↑↑↑	↑↑↑	↓↓	↓	N	0	0	0
6 GR	↑↑↑	↑↑	N	↑↑	↑	N	2	1	1

Patients	Cellularity			Megakaryopoiesis			Fibrosis
Patients	1	2	3	1	2	3	1	2	3
Group 1
1 SB	↑↑↑	↑	N	↑↑	N	N	1	1	0
2 PM	↑↑↑	N	N	↑	N	N	1	0	0
3 ZH	↑↑↑	↑	N	↑↑	↑	N	3	1	0
4 UP	↑↑↑	N	N	↑↑	N	N	1	0	0
5 SJ	↑↑	N	N	↑	N	↑	1	0	0
6 PF	↑	N	N	N	N	N	0	0	0
7 PE	↑	N	N	↑	N	N	1	0	0
8 HJ	↑↑↑	↑	N	↑	↑	N	0	0	0
9 HaJ	↑↑↑	↑	N	↑	N	N	1	0	0
Group 2
1 HL	↑↑↑	N	↑↑	↑↑	N	↑↑↑	2	1	1
2 UB	↑↑↑	↑	↑↑↑	↑↑	N	↑	2	1	1
3 WH	↑↑↑	↑↑	N	↓	↑	N	2	0	0
4 HR	↑↑	N	↑	N	N	↑	1	0	0
5 ER	↑↑↑	↑	↑	↑↑	N	↑	2	0	0
6 WA	↑↑↑	N	N	↑↑	N	N	2	0	0
7 DA	↑↑↑	N	↑	↑	N	N	1	0	0
8 KG	↑↑↑	↑↑↑	N	↑↑	↑↑	N	2	1	0
Group 3
1 PH	↑↑↑	↑↑↑	↑↑	↓↓	↓↓	↓	4	3	3
2 WF	↑↑↑	N	N	↑↑↑	N	N	4	3	0
3 FM	↑↑↑	↑	↑↑	↑↑	N	↑	3	0	0
4 TJ	↑↑↑	↑	↑	↓↓	N	N	1	1	0
5 LK	↑↑↑	↑↑↑	↑↑↑	↓↓	↓	N	0	0	0
6 GR	↑↑↑	↑↑	N	↑↑	↑	N	2	1	1

1 indicates bone marrow biopsy findings before STI571 treatment; 2, bone marrow biopsy findings after 6 weeks STI571 treatment; 3, bone marrow biopsy findings after 3-month STI571 treatment; ↑↑↑, highly increased; ↑↑, moderately increased; ↑, slightly increased; ↓↓↓, highly decreased; ↓↓, moderately decreased; ↓, slightly decreased; and N, normal.

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